Name: Anti-VANGL1 Antibody (CAB7606)
Brand: Cell Biology Antibodies 11
SKU: CAB7606
Availability: OutOfStock

Antibody Name:	Anti-VANGL1 Antibody
Antibody SKU:	CAB7606
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 275-524 of human VANGL1 (NP_620409.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 275-524 of human VANGL1 (NP_620409.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	AALV VLEN YYKD FTIY NPNL LTAS KFRA AKHM AGLK VYNV DGPS NNAT GQSR AMIA AAAR RRDS SHNE LYYE EAEH ERRV KKRK ARLV VAVE EAFI HIQR LQAE EQQK APGE VMDP REAA QAIF PSMA RALQ KYLR ITRQ QNYH SMES ILQH LAFC ITNG MTPK AFLE RYLS AGPT LQYD KDRW LSTQ WRLV SDEA VTNG LRDG IVFV LKCL DFSL VVNV KKIP FIIL SEEF IDPK SHKF VLRL QSET SV
Gene ID:	81839
Uniprot:	Q8TAA9
Cellular Location:	Cell membrane, Multi-pass membrane protein
Calculated MW:	59kDa
Observed MW:	Refer to figures

Synonyms:	VANGL1, KITENIN, LPP2, STB2, STBM2
Background:	This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants.

UniProt Protein Function:	VANGL1: Defects in VANGL1 are a cause of neural tube defects (NTD). NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis). Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM). SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant. Belongs to the Vang family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Adaptor/scaffold; Membrane protein, multi-pass; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p13.1 Molecular Function:protein binding Disease: Neural Tube Defects; Sacral Defect With Anterior Meningocele
NCBI Summary:	This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
UniProt Code:	Q8TAA9
NCBI GenInfo Identifier:	40807121
NCBI Gene ID:	81839
NCBI Accession:	BC065272
UniProt Secondary Accession:	Q8TAA9,Q5T1D3, Q5T1D4, Q86WG8, Q8N559,
UniProt Related Accession:	Q8TAA9
Molecular Weight:	59,748 Da
NCBI Full Name:	Homo sapiens vang-like 1 (van gogh, Drosophila), mRNA
NCBI Synonym Full Names:	VANGL planar cell polarity protein 1
NCBI Official Symbol:	VANGL1
NCBI Official Synonym Symbols:	LPP2; STB2; STBM2; KITENIN
NCBI Protein Information:	vang-like protein 1
UniProt Protein Name:	Vang-like protein 1
UniProt Synonym Protein Names:	Loop-tail protein 2 homolog; LPP2; Strabismus 2; Van Gogh-like protein 1
Protein Family:	Vang-like protein
UniProt Gene Name:	VANGL1
UniProt Entry Name:	VANG1_HUMAN