| UniProt Protein Function: | VAMP7: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: Xq28 and Yq12Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; neuron projection; cell surface; intracellular membrane-bound organelle; late endosome membrane; secretory granule membrane; lysosomal membrane; integral to membrane; trans-Golgi network; phagocytic vesicle; pseudopodium; secretory granule; SNARE complex; phagocytic vesicle membrane; membrane; apical part of cell; perinuclear region of cytoplasm; lamellipodium; cytoplasm; plasma membrane; synapse; cell junctionMolecular Function: SNAP receptor activity; protein binding; SNARE binding; syntaxin bindingBiological Process: ER to Golgi vesicle-mediated transport; exocytosis; natural killer cell degranulation; autophagic vacuole fusion; neutrophil degranulation; endocytosis; vesicle fusion with Golgi apparatus; calcium ion-dependent exocytosis; vesicle fusion; vesicle-mediated transport; Golgi to plasma membrane protein transport; eosinophil degranulation; endosome to lysosome transport; post-Golgi vesicle-mediated transport; triacylglycerol transport; phagocytosis, engulfment |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010] |
| UniProt Code: | P51809 |
| NCBI GenInfo Identifier: | 1723133 |
| NCBI Gene ID: | 6845 |
| NCBI Accession: | P51809.3 |
| UniProt Secondary Accession: | P51809,Q53GY7, Q7Z409, Q9H4A7 |
| UniProt Related Accession: | P51809 |
| Molecular Weight: | 20,121 Da |
| NCBI Full Name: | Vesicle-associated membrane protein 7 |
| NCBI Synonym Full Names: | vesicle-associated membrane protein 7 |
| NCBI Official Symbol: | VAMP7 |
| NCBI Official Synonym Symbols: | SYBL1; TIVAMP; VAMP-7; TI-VAMP |
| NCBI Protein Information: | vesicle-associated membrane protein 7; synaptobrevin-like 1; tetanus-insensitive VAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insensitive VAMP |
| UniProt Protein Name: | Vesicle-associated membrane protein 7 |
| UniProt Synonym Protein Names: | Synaptobrevin-like protein 1; Tetanus-insensitive VAMP; Ti-VAMP |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP7 |
| UniProt Entry Name: | VAMP7_HUMAN |
