Cell Biology Antibodies 9
Anti-VAMP4 Antibody (CAB4241)
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- SKU:
- CAB4241
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-VAMP4 Antibody |
| Antibody SKU: | CAB4241 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human VAMP4 (NP_003753.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | B cells, HeLa, Jurkat, BT-474, NIH/3T3, Mouse brain, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human VAMP4 (NP_003753.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPPK FKRH LNDD DVTG SVKS ERRN LLED DSDE EEDF FLRG PSGP RFGP RNDK IKHV QNQV DEVI DVMQ ENIT KVIE RGER LDEL QDKS ESLS DNAT AFSN RSKQ LRRQ MWWR GCK |
| Gene ID: | 8674 |
| Uniprot: | O75379 |
| Cellular Location: | Golgi apparatus, Single-pass type IV membrane protein, trans-Golgi network membrane |
| Calculated MW: | 16kDa |
| Observed MW: | 16kDa |
| Synonyms: | VAMP4, VAMP-4, VAMP24 |
| Background: | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. |
| UniProt Protein Function: | VAMP4: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. Belongs to the synaptobrevin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q24-q25 Cellular Component: SNARE complex; Golgi membrane; Golgi apparatus; cell surface; lysosome; integral to membrane; trans-Golgi network; endosome Molecular Function:SNAP receptor activity; SNARE binding Biological Process: regulation of Golgi to plasma membrane protein transport; ER to Golgi vesicle-mediated transport; exocytosis; Golgi to plasma membrane protein transport; microtubule cytoskeleton organization and biogenesis |
| NCBI Summary: | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75379 |
| NCBI GenInfo Identifier: | 20141854 |
| NCBI Gene ID: | 8674 |
| NCBI Accession: | O75379.2 |
| UniProt Related Accession: | O75379 |
| Molecular Weight: | Observed: 16KDPredicted: 17 kDa |
| NCBI Full Name: | Vesicle-associated membrane protein 4 |
| NCBI Synonym Full Names: | vesicle associated membrane protein 4 |
| NCBI Official Symbol: | VAMP4 |
| NCBI Official Synonym Symbols: | VAMP-4; VAMP24 |
| NCBI Protein Information: | vesicle-associated membrane protein 4 |
| UniProt Protein Name: | Vesicle-associated membrane protein 4 |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP4 |
| UniProt Entry Name: | VAMP4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VAMP4 antibody (CAB4241) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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