Immunology Antibodies 2

Anti-VAC14 Antibody (CAB16782)

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SKU:
CAB16782
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-VAC14 Antibody
Antibody SKU:CAB16782
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human VAC14.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human VAC14.
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:55697
Uniprot:Q08AM6
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:TRX, TAX1BP2, ArPIKfyve, VAC14
Background:This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3, 5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities.
UniProt Protein Function:VAC14: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Belongs to the VAC14 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: early endosome membrane; endosome membrane; Golgi membrane; late endosome membrane

Molecular Function:protein binding

Biological Process: phosphatidylinositol biosynthetic process

NCBI Summary:The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010]
UniProt Code:Q08AM6
NCBI GenInfo Identifier:121940040
NCBI Gene ID:55697
NCBI Accession:Q08AM6.1
UniProt Secondary Accession:Q08AM6,Q13174, Q6IA12, Q7L4Y1, Q9BW96, Q9H6V6, B3KPJ5 B3KSM8,
UniProt Related Accession:Q08AM6
Molecular Weight:24,783 Da
NCBI Full Name:Protein VAC14 homolog
NCBI Synonym Full Names:Vac14, PIKFYVE complex component
NCBI Official Symbol:VAC14  
NCBI Official Synonym Symbols:TRX; TAX1BP2; ArPIKfyve  
NCBI Protein Information:protein VAC14 homolog
UniProt Protein Name:Protein VAC14 homolog
UniProt Synonym Protein Names:Tax1-binding protein 2
Protein Family:Vacuole morphology and inheritance protein
UniProt Gene Name:VAC14  
UniProt Entry Name:VAC14_HUMAN
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