Cell Biology Antibodies 9

Anti-UTS2 Antibody (CAB5334)

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SKU:
CAB5334
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-UTS2 Antibody
Antibody SKU:CAB5334
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 35-124 of human UTS2 (NP_006777.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse skeletal muscle, Mouse testis, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 35-124 of human UTS2 (NP_006777.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:APHE DARL TPEE LERA SLLQ ILPE MLGA ERGD ILRK ADSS TNIF NPRG NLRK FQDF SGQD PNIL LSHL LARI WKPY KKRE TPDC FWKY CV
Gene ID:10911
Uniprot:O95399
Cellular Location:Secreted
Calculated MW:14kDa/16kDa
Observed MW:17kDa
Synonyms:UTS2, PRO1068, U-II, UCN2, UII
Background:This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.
UniProt Protein Function:UTS2: Highly potent vasoconstrictor. Belongs to the urotensin-2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: extracellular region

Molecular Function:receptor binding

Biological Process: muscle contraction; regulation of blood pressure; synaptic transmission

NCBI Summary:This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O95399
NCBI GenInfo Identifier:9087195
NCBI Gene ID:10911
NCBI Accession:O95399.1
UniProt Secondary Accession:O95399,Q5H8X7, Q6UXF6, Q9UKP7,
UniProt Related Accession:O95399
Molecular Weight:16,029 Da
NCBI Full Name:Urotensin-2
NCBI Synonym Full Names:urotensin 2
NCBI Official Symbol:UTS2  
NCBI Official Synonym Symbols:UII; U-II; UCN2; PRO1068  
NCBI Protein Information:urotensin-2
UniProt Protein Name:Urotensin-2
UniProt Synonym Protein Names:Urotensin II; U-II; UII
UniProt Gene Name:UTS2  
UniProt Entry Name:UTS2_HUMAN
Anti-UTS2 Antibody (CAB5334)Western blot analysis of extracts of various cell lines, using UTS2 antibody (CAB5334) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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