Anti-USP9X Antibody (CAB9782)

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SKU:
CAB9782
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
DFFRX
Synonyms:
FAF
Synonyms:
FAM
Synonyms:
MRX99
Synonyms:
MRXS99F
Research Area:
Cell Biology

Description

Product Name:USP9X Rabbit mAb
Product Code:CAB9782
Size:20uL, 50uL, 100uL
Synonyms:DFFRX, FAF, FAM, MRX99, MRXS99F
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human USP9X
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, PC-3, C6, U-251MG, Mouse testis, Mouse brain
Immunogen:A synthesized peptide derived from human USP9X
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8239
Uniprot:Q93008
Calculated MW:292kDa
Observed MW:270kDa
UniProt Protein Function:USP9X: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin. Widely expressed in embryonic and adult tissues. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.19.12; Protease; Ubiquitin-specific protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: growth cone; membrane; apical part of cell; cytoplasm; cytosol

Molecular Function:protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; cysteine-type peptidase activity

Biological Process: mitosis; proteasomal ubiquitin-dependent protein catabolic process; transcription initiation from RNA polymerase II promoter; protein deubiquitination; transcription, DNA-dependent; axon extension; in utero embryonic development; hippocampus development; neuron migration; female gamete generation; negative regulation of transcription from RNA polymerase II promoter; cerebellar cortex structural organization; post-embryonic development; chromosome segregation; BMP signaling pathway; cell division; transforming growth factor beta receptor signaling pathway; gene expression

Disease: Mental Retardation, X-linked 99

NCBI Summary:This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q93008
NCBI GenInfo Identifier:317373496
NCBI Gene ID:8239
NCBI Accession:Q93008.3
UniProt Secondary Accession:Q93008,O75550, Q8WWT3, Q8WX12,
UniProt Related Accession:Q93008
Molecular Weight:2570
NCBI Full Name:Probable ubiquitin carboxyl-terminal hydrolase FAF-X
NCBI Synonym Full Names:ubiquitin specific peptidase 9, X-linked
NCBI Official Symbol:USP9X  
NCBI Official Synonym Symbols:FAF; FAM; DFFRX; MRX99  
NCBI Protein Information:probable ubiquitin carboxyl-terminal hydrolase FAF-X; hFAM; fat facets in mammals; ubiquitin thioesterase FAF-X; deubiquitinating enzyme FAF-X; ubiquitin thiolesterase FAF-X; fat facets protein related, X-linked; fat facets protein-related, X-linked; Dros
UniProt Protein Name:Probable ubiquitin carboxyl-terminal hydrolase FAF-X
UniProt Synonym Protein Names:Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X
Protein Family:Probable ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name:USP9X  
UniProt Entry Name:USP9X_HUMAN
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