Signal Transduction Antibodies 1
Anti-USP6 Antibody (CAB13255)
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- SKU:
- CAB13255
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-USP6 Antibody |
| Antibody SKU: | CAB13255 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-120 of human USP6 (NP_004496.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-120 of human USP6 (NP_004496.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELPP VTAR EAKK IRRE MTRT SKWM EMLG EWET YKHS SKLI DRVY KGIP MNIR GPVW SVLL NIQE IK |
| Gene ID: | 9098 |
| Uniprot: | P35125 |
| Cellular Location: | Cell membrane, Cytoplasm, Endosome |
| Calculated MW: | 89kDa/121kDa/158kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | USP6, HRP1, TRE17, TRE2, TRESMCR, Tre-2, USP6-short |
| Background: |
| UniProt Protein Function: | USP6: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; Ubiquitin-specific protease; Protease; EC 3.4.19.12 Chromosomal Location of Human Ortholog: 17p13 Cellular Component: cytoplasm; lysosome; plasma membrane; recycling endosome Molecular Function:calmodulin binding; cysteine-type endopeptidase activity; nucleic acid binding; protein binding; ubiquitin-specific protease activity Biological Process: protein deubiquitination |
| UniProt Code: | P35125 |
| NCBI GenInfo Identifier: | 50403738 |
| NCBI Gene ID: | 9098 |
| NCBI Accession: | P35125.2 |
| UniProt Secondary Accession: | P35125,Q15634, Q86WP6, Q8IWT4, |
| UniProt Related Accession: | P35125 |
| Molecular Weight: | 89,577 Da |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 6 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 6 |
| NCBI Official Symbol: | USP6 |
| NCBI Official Synonym Symbols: | HRP1; TRE2; TRE17; Tre-2; TRESMCR; USP6-short |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 6 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 6 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 6; Proto-oncogene TRE-2; Ubiquitin thioesterase 6; Ubiquitin-specific-processing protease 6 |
| Protein Family: | USP6 N-terminal-like protein |
| UniProt Gene Name: | USP6 |
| UniProt Entry Name: | UBP6_HUMAN |
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