Signal Transduction Antibodies 2

Anti-USP48 Antibody (CAB5046)

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SKU:
CAB5046
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
USP48
Synonyms:
RAP1GA1
Synonyms:
USP31

Description

Product Name:USP48 Rabbit pAb
Product Code:CAB5046
Size:20uL, 50uL, 100uL
Synonyms:USP48, RAP1GA1, USP31
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human USP48 (NP_115612.4).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, HT-29, HeLa, A375, Mouse lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human USP48 (NP_115612.4).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAPR LQLE KAAW RWAE TVRP EEVS QEHI ETAY RIWL EPCI RGVC RRNC KGNP NCLV GIGE HIWL GEID ENSF HNID DPNC ERRK KNSF VGLT NLGA TCYV NTFL QVWF LNLE LRQA LYLC PSTC SDYM LGDG IQEE KDYE PQTI CEHL QYLF ALLQ NSNR RYID PSGF VKAL GLDT GQQQ DAQE FSKL FMSL LEDT LSKQ KNPD VRNI VQQQ FCGE YAYV TVCN QCGR ESKL LSKF YELE LNIQ GHKQ LTDC ISEF LKEE KLEG DNRY FCEN CQSK QNAT RKIR LLSL PCTL NLQL MRFV
Gene ID:84196
Uniprot:Q86UV5
Cellular Location:Cytoplasm, Nucleus
Calculated MW:17kDa/45-59kDa/81kDa/112-120kDa
Observed MW:119kDa
UniProt Protein Function:USP48: Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Belongs to the peptidase C19 family. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; Ubiquitin-specific protease; EC 3.4.19.12; Protease

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: nucleoplasm; mitochondrion; cytoplasm

Molecular Function:cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination

NCBI Summary:This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q86UV5
NCBI GenInfo Identifier:74750436
NCBI Gene ID:84196
NCBI Accession:Q86UV5.1
UniProt Secondary Accession:Q86UV5,Q2M3I4, Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64 Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, B7ZKS7,
UniProt Related Accession:Q86UV5
Molecular Weight:1035
NCBI Full Name:Ubiquitin carboxyl-terminal hydrolase 48
NCBI Synonym Full Names:ubiquitin specific peptidase 48
NCBI Official Symbol:USP48  
NCBI Official Synonym Symbols:USP31; RAP1GA1  
NCBI Protein Information:ubiquitin carboxyl-terminal hydrolase 48; ubiquitin thioesterase 48; deubiquitinating enzyme 48; ubiquitin thiolesterase 48; ubiquitin specific protease 31; ubiquitin specific protease 48; ubiquitin-specific-processing protease 48
UniProt Protein Name:Ubiquitin carboxyl-terminal hydrolase 48
UniProt Synonym Protein Names:Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48
Protein Family:Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name:USP48  
UniProt Entry Name:UBP48_HUMAN
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