Developmental Biology
Anti-USP46 Antibody (CAB17863)
- SKU:
- CAB17863
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-USP46 Antibody |
| Antibody SKU: | CAB17863 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic Peptide of human USP46 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | mouse pancreas |
| Immunogen: | A synthetic Peptide of human USP46 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 64854 |
| Uniprot: | P62068 |
| Cellular Location: | |
| Calculated MW: | 26kDa/41kDa/42kDa |
| Observed MW: | 42kDa |
| Synonyms: | USP46 |
| Background: |
| UniProt Protein Function: | USP46: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Belongs to the peptidase C19 family. USP12/USP46 subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.19.12; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 4q12 Molecular Function:protein binding; ubiquitin-specific protease activity Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; behavioral fear response; righting reflex; adult feeding behavior; behavioral response to ethanol; regulation of synaptic transmission, GABAergic |
| NCBI Summary: | Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | P62068 |
| NCBI GenInfo Identifier: | 49065850 |
| NCBI Gene ID: | 64854 |
| NCBI Accession: | P62068.1 |
| UniProt Secondary Accession: | P62068,Q80V95, Q9H7U4, Q9H9T8, B7Z3Y7, B7Z675, B7Z7S3 G8ACC7, |
| UniProt Related Accession: | P62068 |
| Molecular Weight: | 366 |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 46 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 46 |
| NCBI Official Symbol: | USP46 |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 46; ubiquitin thioesterase 46; deubiquitinating enzyme 46; ubiquitin thiolesterase 46; ubiquitin-specific-processing protease 46 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 46 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46 |
| Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | USP46 |
| UniProt Entry Name: | UBP46_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using USP46 antibody (CAB17863) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of C6 cells using USP46 Polyclonal Antibody (CAB17863) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L-929 cells using USP46 Polyclonal Antibody (CAB17863) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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