Signal Transduction Antibodies 2

Anti-USP40 Antibody (CAB15856)

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SKU:
CAB15856
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-USP40 Antibody
Antibody SKU:CAB15856
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1173-1247 of human USP40 (NP_060688.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, Mouse pancreas, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1173-1247 of human USP40 (NP_060688.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GDTI GVKN LLID DDDD FSTI RDDT GKEK QKQR ALGR RKSQ EALH EQSS YILS SAET PARP RAPE TSLS IHVG SFR
Gene ID:55230
Uniprot:Q9NVE5
Cellular Location:
Calculated MW:18kDa/140kDa/141kDa
Observed MW:140kDa
Synonyms:USP40
Background:Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
UniProt Protein Function:USP40: May be catalytically inactive. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin-specific protease; Cell adhesion; Hydrolase; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cytoplasm; nucleus

NCBI Summary:Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9NVE5
NCBI GenInfo Identifier:59803114
NCBI Gene ID:55230
NCBI Accession:Q9NVE5.3
UniProt Secondary Accession:Q9NVE5,Q6NX38, Q70EL0,
UniProt Related Accession:Q9NVE5
Molecular Weight:141,558 Da
NCBI Full Name:Ubiquitin carboxyl-terminal hydrolase 40
NCBI Synonym Full Names:ubiquitin specific peptidase 40
NCBI Official Symbol:USP40  
NCBI Protein Information:ubiquitin carboxyl-terminal hydrolase 40
UniProt Protein Name:Ubiquitin carboxyl-terminal hydrolase 40
UniProt Synonym Protein Names:Deubiquitinating enzyme 40; Ubiquitin thioesterase 40; Ubiquitin-specific-processing protease 40
Protein Family:Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name:USP40  
UniProt Entry Name:UBP40_HUMAN
Anti-USP40 Antibody (CAB15856)Western blot analysis of extracts of various cell lines, using USP40 antibody (CAB15856) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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