Signal Transduction Antibodies 1

Anti-USP30 Antibody (CAB12862)

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SKU:
CAB12862
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-USP30 Antibody
Antibody SKU:CAB12862
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 57-390 of human USP30 (NP_116052.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 57-390 of human USP30 (NP_116052.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TERK KRRK GLVP GLVN LGNT CFMN SLLQ GLSA CPAF IRWL EEFT SQYS RDQK EPPS HQYL SLTL LHLL KALS CQEV TDDE VLDA SCLL DVLR MYRW QISS FEEQ DAHE LFHV ITSS LEDE RDRQ PRVT HLFD VHSL EQQS EITP KQIT CRTR GSPH PTSN HWKS QHPF HGRL TSNM VCKH CEHQ SPVR FDTF DSLS LSIP AATW GHPL TLDH CLHH FISS ESVR DVVC DNCT KIEA KGTL NGEK VEHQ RTTF VKQL KLGK LPQC LCIH LQRL SWSS HGTP LKRH EHVQ FNEF LMMD IYKY HLLG HKPS QHNP KLNK NPGP TLEL QDGP GAPT PV
Gene ID:84749
Uniprot:Q70CQ3
Cellular Location:Mitochondrion outer membrane
Calculated MW:58kDa
Observed MW:71kDa
Synonyms:USP30
Background:
UniProt Protein Function:USP30: May participate in the maintenance of mitochondrial morphology. Belongs to the peptidase C19 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 3.4.19.12; Protease; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane

Molecular Function:cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; mitochondrial fusion; mitochondrion degradation

NCBI Summary:USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]
UniProt Code:Q70CQ3
NCBI GenInfo Identifier:164607167
NCBI Gene ID:84749
NCBI Accession:NP_116052.2
UniProt Secondary Accession:Q70CQ3,Q8WTU7, Q96JX4, Q9BSS3,
UniProt Related Accession:Q70CQ3
Molecular Weight:58,503 Da
NCBI Full Name:ubiquitin carboxyl-terminal hydrolase 30
NCBI Synonym Full Names:ubiquitin specific peptidase 30
NCBI Official Symbol:USP30  
NCBI Protein Information:ubiquitin carboxyl-terminal hydrolase 30; ub-specific protease 30; ubiquitin thioesterase 30; deubiquitinating enzyme 30; ubiquitin thiolesterase 30; ubiquitin specific protease 30; ubiquitin-specific protease 30; ubiquitin-specific-processing protease 30
UniProt Protein Name:Ubiquitin carboxyl-terminal hydrolase 30
UniProt Synonym Protein Names:Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30
Protein Family:Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name:USP30  
UniProt Entry Name:UBP30_HUMAN
Anti-USP30 Antibody (CAB12862)Western blot analysis of extracts of various cell lines, using USP30 antibody (CAB12862) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-USP30 Antibody (CAB12862)Immunofluorescence analysis of NIH-3T3 cells using USP30 Polyclonal Antibody (CAB12862) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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