Epigenetics & Nuclear Signaling Antibodies 1
Anti-URM1 Antibody (CAB13817)
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- SKU:
- CAB13817
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-URM1 Antibody |
| Antibody SKU: | CAB13817 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human URM1 (NP_001252511.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Rat eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human URM1 (NP_001252511.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAP LSVE VEFG GGAE LLFD GIKK HRVT LPGQ EEPW DIRN LLIW IKKN LLKE RPEL FIQG DSV |
| Gene ID: | 81605 |
| Uniprot: | Q9BTM9 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 7kDa/11kDa/15kDa |
| Observed MW: | 11kDa |
| Synonyms: | URM1, C9orf74 |
| Background: |
| UniProt Protein Function: | URM1: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo. Belongs to the URM1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: cytosol Molecular Function:protein binding; sulfurtransferase activity Biological Process: tRNA modification; tRNA wobble uridine modification |
| UniProt Code: | Q9BTM9 |
| NCBI GenInfo Identifier: | 68565265 |
| NCBI Gene ID: | 81605 |
| NCBI Accession: | Q9BTM9.1 |
| UniProt Secondary Accession: | Q9BTM9,Q5T4B4, B3KMH3, B4DV08, |
| UniProt Related Accession: | Q9BTM9 |
| Molecular Weight: | 7,143 Da |
| NCBI Full Name: | Ubiquitin-related modifier 1 |
| NCBI Synonym Full Names: | ubiquitin related modifier 1 |
| NCBI Official Symbol: | URM1 |
| NCBI Official Synonym Symbols: | C9orf74 |
| NCBI Protein Information: | ubiquitin-related modifier 1 |
| UniProt Protein Name: | Ubiquitin-related modifier 1 |
| Protein Family: | Ubiquitin-related modifier |
| UniProt Gene Name: | URM1 |
| UniProt Entry Name: | URM1_HUMAN |
 | Western blot analysis of extracts of rat eye, using URM1 antibody (CAB13817) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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