Cell Biology Antibodies 3
Anti-UPP1 Antibody (CAB13051)
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- SKU:
- CAB13051
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-UPP1 Antibody |
| Antibody SKU: | CAB13051 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 89-173 of human UPP1 (NP_001274357.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29, A-431, A-549, 293T, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 89-173 of human UPP1 (NP_001274357.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SYTE KDKQ AYLE AAYA AGVR NIEM ESSV FAAM CSAC GLQA AVVC VTLL NRLE GDQI SSPR NVLS EYQQ RPQR LVSY FIKK KLSK A |
| Gene ID: | 7378 |
| Uniprot: | Q16831 |
| Cellular Location: | |
| Calculated MW: | 3kDa/33kDa |
| Observed MW: | 36kDa |
| Synonyms: | UPP1, UDRPASE, UP, UPASE, UPP |
| Background: | This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. |
| UniProt Protein Function: | UPP1: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; EC 2.4.2.3; Transferase Chromosomal Location of Human Ortholog: 7p12.3 Cellular Component: cytosol Molecular Function:uridine phosphorylase activity Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage |
| NCBI Summary: | The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009] |
| UniProt Code: | Q16831 |
| NCBI GenInfo Identifier: | 2494059 |
| NCBI Gene ID: | 7378 |
| NCBI Accession: | Q16831.1 |
| UniProt Secondary Accession: | Q16831,Q15362, D3DVM4, |
| UniProt Related Accession: | Q16831 |
| Molecular Weight: | 3,694 Da |
| NCBI Full Name: | Uridine phosphorylase 1 |
| NCBI Synonym Full Names: | uridine phosphorylase 1 |
| NCBI Official Symbol: | UPP1 |
| NCBI Official Synonym Symbols: | UP; UPP; UPASE; UDRPASE |
| NCBI Protein Information: | uridine phosphorylase 1 |
| UniProt Protein Name: | Uridine phosphorylase 1 |
| Protein Family: | Uridine phosphorylase |
| UniProt Gene Name: | UPP1 |
| UniProt Entry Name: | UPP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UPP1 Antibody (CAB13051) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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