Cell Biology Antibodies 2

Anti-UPK2 Antibody (CAB10813)

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SKU:
CAB10813
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-UPK2 Antibody
Antibody SKU:CAB10813
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 85-155 of human UPK2 (NP_006751.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:B-cell
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 85-155 of human UPK2 (NP_006751.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ELVS VVDS GAGF TVTR LSAY QVTN LVPG TKFY ISYL VKKG TATE SSRE IPMS TLPR RNME SIGL GMAR TGG
Gene ID:7379
Uniprot:O00526
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:19kDa
Observed MW:19kDa
Synonyms:UPK2, UP2, UPII
Background:This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.
UniProt Protein Function:UPK2: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM. Belongs to the uroplakin-2 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: integral to plasma membrane; apical plasma membrane; integral to endoplasmic reticulum membrane

Biological Process: epithelial cell differentiation; multicellular organismal development

NCBI Summary:This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
UniProt Code:O00526
NCBI GenInfo Identifier:6707761
NCBI Gene ID:7379
NCBI Accession:O00526.2
UniProt Secondary Accession:O00526,O00457, Q53YV0, B0YJ92,
UniProt Related Accession:O00526
Molecular Weight:184
NCBI Full Name:Uroplakin-2
NCBI Synonym Full Names:uroplakin 2
NCBI Official Symbol:UPK2  
NCBI Official Synonym Symbols:UP2; UPII  
NCBI Protein Information:uroplakin-2; uroplakin II
UniProt Protein Name:Uroplakin-2
UniProt Synonym Protein Names:Uroplakin II; UPII
Protein Family:Uroplakin
UniProt Gene Name:UPK2  
UniProt Entry Name:UPK2_HUMAN
Anti-UPK2 Antibody (CAB10813)Western blot analysis of extracts of B-cell cells, using UPK2 antibody (CAB10813) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 40s.
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