Cell Biology Antibodies 3

Anti-UPK1A Antibody (CAB12761)

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SKU:
CAB12761
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-UPK1A Antibody
Antibody SKU:CAB12761
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-230 of human UPK1A (NP_008931.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse testis, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-230 of human UPK1A (NP_008931.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SCIT SYTH RDYM VSNP SLIT KQML TFYS ADTD QGQE LTRL WDRV MIEQ ECCG TSGP MDWV NFTS AFRA ATPE VVFP WPPL CCRR TGNF IPLN EEGC RLGH MDYL FTKG CFEH IGHA IDSY T
Gene ID:11045
Uniprot:O00322
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:28kDa/30kDa
Observed MW:29kDa
Synonyms:UPK1A, TSPAN21, UP1A, UPIA, UPKA
Background:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene.
UniProt Protein Function:UPK1A: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Belongs to the tetraspanin (TM4SF) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: endoplasmic reticulum; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:protein homodimerization activity

Biological Process: cell surface receptor linked signal transduction; epithelial cell differentiation; protein oligomerization

NCBI Summary:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
UniProt Code:O00322
NCBI GenInfo Identifier:2501226
NCBI Gene ID:11045
NCBI Accession:O00322.1
UniProt Secondary Accession:O00322,Q3KNU5, Q3KNU6,
UniProt Related Accession:O00322
Molecular Weight:29kDa
NCBI Full Name:Uroplakin-1a
NCBI Synonym Full Names:uroplakin 1A
NCBI Official Symbol:UPK1A  
NCBI Official Synonym Symbols:UP1A; UPIA; UPKA; TSPAN21  
NCBI Protein Information:uroplakin-1a
UniProt Protein Name:Uroplakin-1a
UniProt Synonym Protein Names:Tetraspanin-21; Tspan-21; Uroplakin Ia; UPIa; UPKa
Protein Family:Uroplakin
UniProt Gene Name:UPK1A  
Anti-UPK1A Antibody (CAB12761)Western blot analysis of extracts of various cell lines, using UPK1A antibody (CAB12761) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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