Epigenetics & Nuclear Signaling Antibodies 1

Anti-UNG Antibody (CAB13155)

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SKU:
CAB13155
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-UNG Antibody
Antibody SKU:CAB13155
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UNG (NP_550433.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse skeletal muscle, Mouse heart, Rat skeletal muscle
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UNG (NP_550433.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MIGQ KTLY SFFS PSPA RKRH APSP EPAV QGTG VAGV PEES GDAA AIPA KKAP AGQE EPGT PPSS PLSA EQLD RIQR NKAA ALLR LAAR NVPV GFGE SWKK
Gene ID:7374
Uniprot:P13051
Cellular Location:Mitochondrion, Nucleus
Calculated MW:33kDa/34kDa
Observed MW:38kDa
Synonyms:UNG, DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2
Background:This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.
UniProt Protein Function:Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
NCBI Summary:This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
UniProt Code:P13051
NCBI GenInfo Identifier:6224979
NCBI Gene ID:7374
NCBI Accession:NP_003353.1
UniProt Secondary Accession:P13051,O00637, O00719, Q93028, A8K5M6, B2R8Y1,
UniProt Related Accession:P13051
Molecular Weight:
NCBI Full Name:uracil-DNA glycosylase isoform UNG1
NCBI Synonym Full Names:uracil DNA glycosylase
NCBI Official Symbol:UNG  
NCBI Official Synonym Symbols:DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15  
NCBI Protein Information:uracil-DNA glycosylase
UniProt Protein Name:Uracil-DNA glycosylase
Protein Family:Probable uracil-DNA glycosylase
UniProt Gene Name:UNG  
Anti-UNG Antibody (CAB13155)Western blot analysis of extracts of various cell lines, using UNG antibody (CAB13155) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-UNG Antibody (CAB13155)Immunofluorescence analysis of HeLa cells using UNG antibody (CAB13155) at dilution of 1:100. Blue: DAPI for nuclear staining.
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