Epigenetics & Nuclear Signaling Antibodies 1
Anti-UNG Antibody (CAB1261)
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- SKU:
- CAB1261
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-UNG Antibody |
| Antibody SKU: | CAB1261 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human UNG (NP_550433.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Jurkat, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human UNG (NP_550433.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MIGQ KTLY SFFS PSPA RKRH APSP EPAV QGTG VAGV PEES GDAA AIPA KKAP AGQE EPGT PPSS PLSA EQLD RIQR NKAA ALLR LAAR NVPV GFGE SWKK HLSG EFGK PYFI KLMG FVAE ERKH YTVY PPPH QVFT WTQM CDIK DVKV VILG QDPY HGPN QAHG LCFS VQRP VPPP PSLE NIYK ELST DIED FVHP GHGD LSGW AKQG VLLL NAVL TVRA HQAN SHKE RGWE QFTD AVVS WLNQ NSNG LVFL LWGS YAQK KGSA IDRK RHHV LQTA HPSP LSVY RGFF GCRH FSKT NELL QKSG KKPI DWKE L |
| Gene ID: | 7374 |
| Uniprot: | P13051 |
| Cellular Location: | Mitochondrion, Nucleus |
| Calculated MW: | 33kDa/34kDa |
| Observed MW: | 37kDa |
| Synonyms: | UNG, DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2 |
| Background: | This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. |
| UniProt Protein Function: | Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. |
| NCBI Summary: | This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P13051 |
| NCBI GenInfo Identifier: | 6224979 |
| NCBI Gene ID: | 7374 |
| NCBI Accession: | NP_003353.1 |
| UniProt Secondary Accession: | P13051,O00637, O00719, Q93028, A8K5M6, B2R8Y1, |
| UniProt Related Accession: | P13051 |
| Molecular Weight: | |
| NCBI Full Name: | uracil-DNA glycosylase isoform UNG1 |
| NCBI Synonym Full Names: | uracil DNA glycosylase |
| NCBI Official Symbol: | UNG |
| NCBI Official Synonym Symbols: | DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15 |
| NCBI Protein Information: | uracil-DNA glycosylase |
| UniProt Protein Name: | Uracil-DNA glycosylase |
| Protein Family: | Probable uracil-DNA glycosylase |
| UniProt Gene Name: | UNG |
 | Western blot analysis of extracts of various cell lines, using UNG antibody (CAB1261) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human stomach using UNG antibody (CAB1261) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using UNG antibody (CAB1261) at dilution of 1:100 (40x lens). |
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