Immunology Antibodies 1
Anti-UNC93B1 Antibody (CAB15250)
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- SKU:
- CAB15250
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-UNC93B1 Antibody |
| Antibody SKU: | CAB15250 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_112192.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HeLa, Mouse kidney, Mouse lung, Mouse spleen, Rat kidney, Rat lung, Rat spleen |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_112192.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KTGL STLL GILY EDKE RQDF IFTI YHWW QAVA IFTV YLGS SLHM KAKL AVLL VTLV AAAV SYLR MEQK LRRG VAPR QPRI PRPQ HKVR GYRY LEED NSDE S |
| Gene ID: | 81622 |
| Uniprot: | Q9H1C4 |
| Cellular Location: | Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Multi-pass membrane protein, phagosome |
| Calculated MW: | 66kDa |
| Observed MW: | 70kDa |
| Synonyms: | UNC93B1, IIAE1, UNC93, UNC93B, Unc-93B1 |
| Background: | This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. |
| UniProt Protein Function: | UNC93B1: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. Defects in UNC93B1 are associated with herpes simplex encephalitis type 1 (HSE1). HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Mutations in UNC93B1 resulting in autosomal recessive UNC93B1 deficieny predispose otherwise healthy individuals to isolated herpes simplex encephalitis due to impaired IFNs production. UNC93B1 deficieny, however, does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Belongs to the unc-93 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 11q13 Cellular Component: Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum; lysosome; integral to membrane; endosome Biological Process: intracellular protein transport; toll-like receptor signaling pathway; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; toll-like receptor 9 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 7 signaling pathway; defense response to virus Disease: Herpes Simplex Encephalitis, Susceptibility To, 1 |
| NCBI Summary: | This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q9H1C4 |
| NCBI GenInfo Identifier: | 116284350 |
| NCBI Gene ID: | 81622 |
| NCBI Accession: | AAH33623 |
| UniProt Secondary Accession: | Q9H1C4,O95764, Q569H6, Q710D4, |
| UniProt Related Accession: | Q9H1C4 |
| Molecular Weight: | 66,631 Da |
| NCBI Full Name: | UNC93B1 protein, partial |
| NCBI Synonym Full Names: | unc-93 homolog B1 (C. elegans) |
| NCBI Official Symbol: | UNC93B1 |
| NCBI Official Synonym Symbols: | IIAE1; UNC93; UNC93B; Unc-93B1 |
| NCBI Protein Information: | protein unc-93 homolog B1 |
| UniProt Protein Name: | Protein unc-93 homolog B1 |
| UniProt Gene Name: | UNC93B1 |
| UniProt Entry Name: | UN93B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UNC93B1 antibody (CAB15250) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15S. |
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