Cell Biology Antibodies 17
Anti-UNC45A Antibody (CAB18474)
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- SKU:
- CAB18474
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-UNC45A Antibody |
| Antibody SKU: | CAB18474 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human UNC45A. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human UNC45A. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55898 |
| Uniprot: | Q9H3U1 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A, UNC45A |
| Background: |
| UniProt Protein Function: | UNC45A: Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Cytoskeletal Chromosomal Location of Human Ortholog: 15q26.1 Cellular Component: nucleus; perinuclear region of cytoplasm Molecular Function:Hsp90 protein binding; protein binding Biological Process: cell differentiation; muscle development |
| NCBI Summary: | UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9H3U1 |
| NCBI GenInfo Identifier: | 74761419 |
| NCBI Gene ID: | 55898 |
| NCBI Accession: | Q9H3U1.1 |
| UniProt Secondary Accession: | Q9H3U1,Q7L3Y6, Q9H3U8, Q9NSE8, Q9NSE9, A8K6F7, |
| UniProt Related Accession: | Q9H3U1 |
| Molecular Weight: | 24,689 Da |
| NCBI Full Name: | Protein unc-45 homolog A |
| NCBI Synonym Full Names: | unc-45 myosin chaperone A |
| NCBI Official Symbol: | UNC45A |
| NCBI Official Synonym Symbols: | SMAP1; SMAP-1; GCUNC45; UNC-45A; GC-UNC45; GCUNC-45; IRO039700 |
| NCBI Protein Information: | protein unc-45 homolog A |
| UniProt Protein Name: | Protein unc-45 homolog A |
| UniProt Synonym Protein Names: | GCUNC-45; Smooth muscle cell-associated protein 1; SMAP-1 |
| Protein Family: | Protein |
| UniProt Gene Name: | UNC45A |
| UniProt Entry Name: | UN45A_HUMAN |
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