Anti-ULK3 Antibody (CAB5959)
- SKU:
- CAB5959
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Autophagy
Description
| Product Name: | ULK3 Rabbit mAb |
| Product Code: | CAB5959 |
| Size: | 20uL, 50uL, 100uL |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ULK3 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthesized peptide derived from human ULK3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 25989 |
| Uniprot: | Q6PHR2 |
| Calculated MW: | 53kDa |
| UniProt Protein Function: | ULK3: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; ULK family Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: cytoplasm Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: autophagy; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway; protein amino acid autophosphorylation |
| UniProt Code: | Q6PHR2 |
| NCBI GenInfo Identifier: | 259016166 |
| NCBI Gene ID: | 25989 |
| NCBI Accession: | Q6PHR2.2 |
| UniProt Secondary Accession: | Q6PHR2,Q9NPN5, Q9UFS4, B2RXK3, B4DFT0, B4DRQ7, D3DW68 |
| UniProt Related Accession: | Q6PHR2 |
| Molecular Weight: | 54,997 Da |
| NCBI Full Name: | Serine/threonine-protein kinase ULK3 |
| NCBI Synonym Full Names: | unc-51 like kinase 3 |
| NCBI Official Symbol: | ULK3 |
| NCBI Protein Information: | serine/threonine-protein kinase ULK3 |
| UniProt Protein Name: | Serine/threonine-protein kinase ULK3 |
| UniProt Synonym Protein Names: | Unc-51-like kinase 3 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | ULK3 |
| UniProt Entry Name: | ULK3_HUMAN |
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