Name: Anti-UGT2B15 Antibody (CAB16657)
Brand: Cell Biology Antibodies 7
SKU: CAB16657
Availability: OutOfStock

Antibody Name:	Anti-UGT2B15 Antibody
Antibody SKU:	CAB16657
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human UGT2B15 (NP_001067.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HT-29, HepG2, MCF7, BT-474, LO2, mouse liver, rat liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human UGT2B15 (NP_001067.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	ASTL VNAS KSSA IKLE VYPT SLTK NYLE DSLL KILD RWIY GVSK NTFW SYFS QLQE LCWE YYDY SNKL CKDA VLNK KLMM KLQE SKFD VILA DALN PCGE LLAE LFNI PFLY SLRF SVGY TFEK NGGG FLF
Gene ID:	7366
Uniprot:	P54855
Cellular Location:
Calculated MW:	61kDa
Observed MW:	61kDa

Synonyms:	UGT2B15, HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8
Background:	This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4.

UniProt Protein Function:	UGT2B15: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. Belongs to the UDP-glycosyltransferase family.
UniProt Protein Details:	Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - ascorbate and aldarate; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - starch and sucrose; Membrane protein, integral; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase Chromosomal Location of Human Ortholog: 4q13 Cellular Component: intracellular membrane-bound organelle Molecular Function:glucuronosyltransferase activity; retinoic acid binding Biological Process: flavonoid biosynthetic process; steroid metabolic process; xenobiotic metabolic process
NCBI Summary:	This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. [provided by RefSeq, Oct 2011]
UniProt Code:	P54855
NCBI GenInfo Identifier:	332278237
NCBI Gene ID:	7366
NCBI Accession:	P54855.3
UniProt Secondary Accession:	P54855,P23765, Q9UK63, A6NDX0, A6NNJ4, A8K054,
UniProt Related Accession:	P54855,AAB28536
Molecular Weight:	61,036 Da
NCBI Full Name:	UDP-glucuronosyltransferase 2B15
NCBI Synonym Full Names:	UDP glucuronosyltransferase family 2 member B15
NCBI Official Symbol:	UGT2B15
NCBI Official Synonym Symbols:	HLUG4; UGT2B8; UDPGTH3; UDPGT 2B8; UDPGT2B15
NCBI Protein Information:	UDP-glucuronosyltransferase 2B15
UniProt Protein Name:	UDP-glucuronosyltransferase 2B15
UniProt Synonym Protein Names:	HLUG4; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UDPGTh-3
Protein Family:	UDP-glucuronosyltransferase
UniProt Gene Name:	UGT2B15
UniProt Entry Name:	UDB15_HUMAN

	Western blot analysis of extracts of various cell lines, using UGT2B15 antibody (CAB16657) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
	Immunohistochemistry of paraffin-embedded rat kidney using UGT2B15 antibody (CAB16657) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human oophoroma using UGT2B15 antibody (CAB16657) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse spleen using UGT2B15 antibody (CAB16657) at dilution of 1:100 (40x lens).