Cell Biology Antibodies 7

Anti-UGT1A10 Antibody (CAB16537)

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SKU:
CAB16537
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-UGT1A10 Antibody
Antibody SKU:CAB16537
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human UGT1A10 (NP_061948.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:LO2, 293T, A375
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human UGT1A10 (NP_061948.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LRGH EVVV VMPE VSWQ LERS LNCT VKTY STSY TLED QNRE FMVF AHAQ WKAQ AQSI FSLL MSSS SGFL DLFF SHCR SLFN DRKL VEYL KESS FDAV FLDP F
Gene ID:54575
Uniprot:Q9HAW8
Cellular Location:Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein
Calculated MW:49kDa/59kDa
Observed MW:60kDa
Synonyms:UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J
Background:This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.
UniProt Protein Function:Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
UniProt Protein Details:

Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein

Potential.

Tissue specificity: Liver and colon. Ref.1

Sequence similarities: Belongs to the UDP-glycosyltransferase family.

NCBI Summary:This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008]
UniProt Code:Q9HAW8
NCBI GenInfo Identifier:29789078
NCBI Gene ID:54575
NCBI Accession:NP_061948
UniProt Related Accession:Q9HAW8
Molecular Weight:
NCBI Full Name:UDP-glucuronosyltransferase 1-10
NCBI Synonym Full Names:UDP glucuronosyltransferase family 1 member A10
NCBI Official Symbol:UGT1A10  
NCBI Official Synonym Symbols:GNT1; UGT1; UDPGT; UGT1A; UGT1J; UGT-1A; UGT-1J; UGT1.1; UGT1A1; UGT1-01; UGT1-10; UGT1.10; hUG-BR1  
NCBI Protein Information:UDP-glucuronosyltransferase 1-10
UniProt Protein Name:UDP-glucuronosyltransferase 1-10
UniProt Synonym Protein Names:UDP-glucuronosyltransferase 1-J; UGT-1J; UGT1J; UDP-glucuronosyltransferase 1A10
Protein Family:UDP-glucuronosyltransferase
UniProt Gene Name:UGT1A10  
UniProt Entry Name:UD110_HUMAN
Anti-UGT1A10 Antibody (CAB16537)Western blot analysis of extracts of various cell lines, using UGT1A10 antibody (CAB16537) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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