Cell Biology Antibodies 9

Anti-UGGT1 Antibody (CAB4866)

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SKU:
CAB4866
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
UGGT1
Synonyms:
HUGT1
Synonyms:
UGCGL1
Synonyms:
UGT1
Research Area:
Cell Biology

Description

Product Name:UGGT1 Rabbit pAb
Product Code:CAB4866
Size:20uL, 50uL, 100uL
Synonyms:UGGT1, HUGT1, UGCGL1, UGT1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1456-1555 of human UGGT1 (NP_064505.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, 293T, HepG2, HL-60, HT-1080, Mouse liver, Mouse kidney, Rat liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1456-1555 of human UGGT1 (NP_064505.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PNNM IHQV PIKS LPQE WLWC ETWC DDAS KKRA KTID LCNN PMTK EPKL EAAV RIVP EWQD YDQE IKQL QIRF QKEK ETGA LYKE KTKE PSRE GPQK REEL
Gene ID:56886
Uniprot:Q9NYU2
Cellular Location:Endoplasmic reticulum lumen, Endoplasmic reticulum-Golgi intermediate compartment
Calculated MW:174kDa/177kDa
Observed MW:177kDa
UniProt Protein Function:UGCGL1: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transferase; EC 2.4.1.-

Chromosomal Location of Human Ortholog: 2q14.3

Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment

Molecular Function:unfolded protein binding; UDP-glucose:glycoprotein glucosyltransferase activity

Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

NCBI Summary:UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
UniProt Code:Q9NYU2
NCBI GenInfo Identifier:224471872
NCBI Gene ID:56886
NCBI Accession:Q9NYU2.3
UniProt Secondary Accession:Q9NYU2,Q53QP2, Q53SL3, Q8IW30, Q9H8I4,
UniProt Related Accession:Q9NYU2
Molecular Weight:1555
NCBI Full Name:UDP-glucose:glycoprotein glucosyltransferase 1
NCBI Synonym Full Names:UDP-glucose glycoprotein glucosyltransferase 1
NCBI Official Symbol:UGGT1  
NCBI Official Synonym Symbols:UGT1; HUGT1; UGCGL1  
NCBI Protein Information:UDP-glucose:glycoprotein glucosyltransferase 1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1
UniProt Protein Name:UDP-glucose:glycoprotein glucosyltransferase 1
UniProt Synonym Protein Names:UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1
Protein Family:UDP-glucose:glycoprotein glucosyltransferase
UniProt Gene Name:UGGT1  
UniProt Entry Name:UGGG1_HUMAN
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