Antibody Name:	Anti-UGDH Antibody
Antibody SKU:	CAB13559
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1).

Application:	IHC
Recommended Dilution:	IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	EGTA IKDL KNPD RVLI GGDE TPEG QRAV QALC AVYE HWVP REKI LTTN TWSS ELSK LAAN AFLA QRIS SINS ISAL CEAT GADV EEVA TAIG MDQR IGNK FLKA SVGF GGSC FQKD VLNL VYLC EALN LPEV ARYW QQVI DMND YQRR RFAS RIID SLFN TVTD KKIA ILGF AFKK DTGD TRES SSIY ISKY LMDE GAHL HIYD PKVP REQI VVDL SHPG VSED DQVS RLVT ISKD PYEA CDGA HAVV ICTE WDMF KELD YERI HKKM LKPA FIFD GRRV LDGL HNEL QTIG FQIE TIGK KVSS KRIP YAPS GEIP KFSL QDPP NKKP KV
Gene ID:	7358
Uniprot:	O60701
Cellular Location:
Calculated MW:	44kDa/47kDa/55kDa
Observed MW:

Synonyms:

UGDH, GDH, UDP-GlcDH, UDPGDH, UGD

Background:

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	UGDH: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Oxidoreductase; Motility/polarity/chemotaxis; Carbohydrate Metabolism - starch and sucrose; EC 1.1.1.22; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - pentose and glucuronate interconversions Chromosomal Location of Human Ortholog: 4p15.1 Cellular Component: nucleoplasm; cytosol Molecular Function:electron carrier activity; NAD binding; UDP-glucose 6-dehydrogenase activity Biological Process: glycosaminoglycan biosynthetic process; xenobiotic metabolic process; gastrulation with mouth forming second; UDP-glucuronate biosynthetic process; UDP-glucose metabolic process
NCBI Summary:	The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Code:	O60701
NCBI GenInfo Identifier:	6175086
NCBI Gene ID:	7358
NCBI Accession:	O60701.1
UniProt Secondary Accession:	O60701,O60589, B3KUU2, B4DN25,
UniProt Related Accession:	O60701
Molecular Weight:	494
NCBI Full Name:	UDP-glucose 6-dehydrogenase
NCBI Synonym Full Names:	UDP-glucose 6-dehydrogenase
NCBI Official Symbol:	UGDH
NCBI Official Synonym Symbols:	GDH; UGD; UDPGDH; UDP-GlcDH
NCBI Protein Information:	UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-glucose dehydrogenase; uridine diphospho-glucose dehydrogenase
UniProt Protein Name:	UDP-glucose 6-dehydrogenase
UniProt Gene Name:	UGDH
UniProt Entry Name:	UGDH_HUMAN

	Immunohistochemistry of paraffin-embedded rat liver using UGDH antibody (CAB13559) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human esophagus using UGDH antibody (CAB13559) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse kidney using UGDH antibody (CAB13559) at dilution of 1:100 (40x lens).