Metabolism Antibodies 1
Anti-UGDH Antibody (CAB1210)
- SKU:
- CAB1210
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-UGDH Antibody |
| Antibody SKU: | CAB1210 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, THP-1, 22Rv1, ES-2, U-937, Mouse kidney, Mouse intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_003350.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EGTA IKDL KNPD RVLI GGDE TPEG QRAV QALC AVYE HWVP REKI LTTN TWSS ELSK LAAN AFLA QRIS SINS ISAL CEAT GADV EEVA TAIG MDQR IGNK FLKA SVGF GGSC FQKD VLNL VYLC EALN LPEV ARYW QQVI DMND YQRR RFAS RIID SLFN TVTD KKIA ILGF AFKK DTGD TRES SSIY ISKY LMDE GAHL HIYD PKVP REQI VVDL SHPG VSED DQVS RLVT ISKD PYEA CDGA HAVV ICTE WDMF KELD YERI HKKM LKPA FIFD GRRV LDGL HNEL QTIG FQIE TIGK KVSS KRIP YAPS GEIP KFSL QDPP NKKP KV |
| Gene ID: | 7358 |
| Uniprot: | O60701 |
| Cellular Location: | |
| Calculated MW: | 44kDa/47kDa/55kDa |
| Observed MW: | 56kDa |
| Synonyms: | UGDH, GDH, UDP-GlcDH, UDPGDH, UGD |
| Background: | The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | UGDH: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Motility/polarity/chemotaxis; Carbohydrate Metabolism - starch and sucrose; EC 1.1.1.22; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - pentose and glucuronate interconversions Chromosomal Location of Human Ortholog: 4p15.1 Cellular Component: nucleoplasm; cytosol Molecular Function:electron carrier activity; NAD binding; UDP-glucose 6-dehydrogenase activity Biological Process: glycosaminoglycan biosynthetic process; xenobiotic metabolic process; gastrulation with mouth forming second; UDP-glucuronate biosynthetic process; UDP-glucose metabolic process |
| NCBI Summary: | The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| UniProt Code: | O60701 |
| NCBI GenInfo Identifier: | 6175086 |
| NCBI Gene ID: | 7358 |
| NCBI Accession: | O60701.1 |
| UniProt Secondary Accession: | O60701,O60589, B3KUU2, B4DN25, |
| UniProt Related Accession: | O60701 |
| Molecular Weight: | 494 |
| NCBI Full Name: | UDP-glucose 6-dehydrogenase |
| NCBI Synonym Full Names: | UDP-glucose 6-dehydrogenase |
| NCBI Official Symbol: | UGDH |
| NCBI Official Synonym Symbols: | GDH; UGD; UDPGDH; UDP-GlcDH |
| NCBI Protein Information: | UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-glucose dehydrogenase; uridine diphospho-glucose dehydrogenase |
| UniProt Protein Name: | UDP-glucose 6-dehydrogenase |
| UniProt Gene Name: | UGDH |
| UniProt Entry Name: | UGDH_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UGDH Antibody (CAB1210) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat brain using UGDH antibody (CAB1210) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using UGDH antibody (CAB1210) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using UGDH antibody (CAB1210). Blue: DAPI for nuclear staining. |
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