Metabolism Antibodies 2
Anti-UGCG Antibody (CAB6317)
- SKU:
- CAB6317
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-UGCG Antibody |
| Antibody SKU: | CAB6317 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human UGCG |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant protein of human UGCG |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7357 |
| Uniprot: | Q16739 |
| Cellular Location: | Golgi apparatus membrane, Multi-pass membrane protein |
| Calculated MW: | 44kDa |
| Observed MW: | 45kDa |
| Synonyms: | UGCG, GCS, GLCT1 |
| Background: | This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. |
| UniProt Protein Function: | UGCG: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a flippase. Belongs to the glycosyltransferase 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transferase; EC 2.4.1.80; Lipid Metabolism - sphingolipid Chromosomal Location of Human Ortholog: 9q31 Cellular Component: Golgi membrane; membrane; integral to membrane Molecular Function:ceramide glucosyltransferase activity Biological Process: epidermis development; glycosphingolipid biosynthetic process; sphingolipid metabolic process; glycosphingolipid metabolic process; glucosylceramide biosynthetic process |
| NCBI Summary: | This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q16739 |
| NCBI GenInfo Identifier: | 2498228 |
| NCBI Gene ID: | 7357 |
| NCBI Accession: | Q16739.1 |
| UniProt Secondary Accession: | Q16739,Q5T258, |
| UniProt Related Accession: | Q16739 |
| Molecular Weight: | |
| NCBI Full Name: | Ceramide glucosyltransferase |
| NCBI Synonym Full Names: | UDP-glucose ceramide glucosyltransferase |
| NCBI Official Symbol: | UGCG |
| NCBI Official Synonym Symbols: | GCS; GLCT1 |
| NCBI Protein Information: | ceramide glucosyltransferase; glucosylceramide synthase; UDP-glucose:N-acylsphingosine D-glucosyltransferase |
| UniProt Protein Name: | Ceramide glucosyltransferase |
| UniProt Synonym Protein Names: | GLCT-1; Glucosylceramide synthase; GCS; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase |
| Protein Family: | Ceramide glucosyltransferase |
| UniProt Gene Name: | UGCG |
| UniProt Entry Name: | CEGT_HUMAN |
 | Western blot analysis of extracts of mouse brain, using UGCG antibody (CAB6317) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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