Signal Transduction Antibodies 2

Anti-UCP2 Antibody (CAB4178)

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SKU:
CAB4178
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-UCP2 Antibody
Antibody SKU:CAB4178
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human UCP2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse spleen
Immunogen:A synthetic peptide of human UCP2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7351
Uniprot:P55851
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:33kDa
Observed MW:33kDa
Synonyms:UCP2, BMIQ4, SLC25A8, UCPH
Background:Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
UniProt Protein Function:UCP2: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Belongs to the mitochondrial carrier family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: mitochondrial inner membrane; integral to membrane

Biological Process: cellular metabolic process; proton transport; response to superoxide; regulation of mitochondrial membrane potential; cellular response to insulin stimulus; transport; cellular response to amino acid starvation; response to hypoxia; female pregnancy; negative regulation of apoptosis; aging; mitochondrial transport

Disease: Body Mass Index Quantitative Trait Locus 4

NCBI Summary:Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
UniProt Code:P55851
NCBI GenInfo Identifier:2497981
NCBI Gene ID:7351
NCBI Accession:P55851.1
UniProt Secondary Accession:P55851,Q4PJH8, Q53HM3,
UniProt Related Accession:P55851
Molecular Weight:309
NCBI Full Name:Mitochondrial uncoupling protein 2
NCBI Synonym Full Names:uncoupling protein 2 (mitochondrial, proton carrier)
NCBI Official Symbol:UCP2  
NCBI Official Synonym Symbols:UCPH; BMIQ4; SLC25A8  
NCBI Protein Information:mitochondrial uncoupling protein 2; solute carrier family 25 member 8
UniProt Protein Name:Mitochondrial uncoupling protein 2
UniProt Synonym Protein Names:Solute carrier family 25 member 8; UCPH
UniProt Gene Name:UCP2  
UniProt Entry Name:UCP2_HUMAN
Anti-UCP2 Antibody (CAB4178)Western blot analysis of extracts of mouse spleen, using UCP2 antibody (CAB4178) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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