Cell Biology Antibodies 2

Anti-UCK2 Antibody (CAB10815)

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SKU:
CAB10815
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-UCK2 Antibody
Antibody SKU:CAB10815
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human UCK2 (NP_036606.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:A-549, HeLa, 293T, B-cell, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human UCK2 (NP_036606.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGD SEQT LQNH QQPN GGEP FLIG VSGG TASG KSSV CAKI VQLL GQNE VDYR QKQV VILS QDSF YRVL TSEQ KAKA LKGQ FNFD HPDA FDNE LILK TLKE ITEG KTVQ IPVY DFVS HSRK EETV TVYP ADVV LFEG ILAF YSQE VRDL FQMK LFVD TDAD TRLS RRVL RDIS ERGR DLEQ ILSQ YITF VKPA FEEF CLPT KKYA DVII PRGA DNLV AINL IVQH IQDI LNGG PSKR QTNG CLNG YTPS RKRQ ASES SSRP H
Gene ID:7371
Uniprot:Q9BZX2
Cellular Location:
Calculated MW:12kDa/29kDa
Observed MW:29kDa
Synonyms:UCK2, TSA903, UK, UMPK
Background:This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.
UniProt Protein Function:UCK2: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine. Belongs to the uridine kinase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.7.1.48; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 1q24.1

Cellular Component: cytosol

Molecular Function:nucleoside kinase activity; uridine kinase activity

Biological Process: pyrimidine base metabolic process; pyrimidine nucleoside salvage

NCBI Summary:This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
UniProt Code:Q9BZX2
NCBI GenInfo Identifier:20455356
NCBI Gene ID:7371
NCBI Accession:Q9BZX2.1
UniProt Secondary Accession:Q9BZX2,Q5VV91, Q7KZV3, Q92528, Q96KG5, Q9BU42,
UniProt Related Accession:Q9BZX2
Molecular Weight:29kDa
NCBI Full Name:Uridine-cytidine kinase 2
NCBI Synonym Full Names:uridine-cytidine kinase 2
NCBI Official Symbol:UCK2  
NCBI Official Synonym Symbols:UK; UMPK; TSA903  
NCBI Protein Information:uridine-cytidine kinase 2
UniProt Protein Name:Uridine-cytidine kinase 2
UniProt Synonym Protein Names:Cytidine monophosphokinase 2; Testis-specific protein TSA903; Uridine monophosphokinase 2
Protein Family:Uridine-cytidine kinase
UniProt Gene Name:UCK2  
Anti-UCK2 Antibody (CAB10815)Western blot analysis of extracts of various cell lines, using UCK2 antibody (CAB10815) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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