Anti-UCHL3 Antibody (CAB1372)
- SKU:
- CAB1372
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- UCH-L3
Description
| Product Name: | UCHL3 Rabbit mAb |
| Product Code: | CAB1372 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | UCH-L3 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human UCHL3 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, 293T, PC-12, C2C12, Jurkat, Mouse brain |
| Immunogen: | A synthesized peptide derived from human UCHL3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7347 |
| Uniprot: | P15374 |
| Calculated MW: | 26kDa |
| Observed MW: | 26kDa |
| UniProt Protein Function: | UCHL3: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates. Highly expressed in heart, skeletal muscle, and testis. Inhibited by monoubiquitin and diubiquitin. Belongs to the peptidase C12 family. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12; Ubiquitin conjugating system; Protease Chromosomal Location of Human Ortholog: 13q22.2 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:peptidase activity; ubiquitin binding; protein binding; ubiquitin-specific protease activity Biological Process: ubiquitin-dependent protein catabolic process; protein catabolic process |
| NCBI Summary: | The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012] |
| UniProt Code: | P15374 |
| NCBI GenInfo Identifier: | 5174741 |
| NCBI Gene ID: | 7347 |
| NCBI Accession: | NP_005993.1 |
| UniProt Secondary Accession: | P15374,Q5TBK8, Q6IBE9, B2R970, |
| UniProt Related Accession: | P15374 |
| Molecular Weight: | 26,183 Da |
| NCBI Full Name: | ubiquitin carboxyl-terminal hydrolase isozyme L3 |
| NCBI Synonym Full Names: | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) |
| NCBI Official Symbol: | UCHL3 |
| NCBI Official Synonym Symbols: | UCH-L3 |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase isozyme L3; OTTHUMP00000018509; ubiquitin thiolesterase; ubiquitin thioesterase L3 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L3 |
| UniProt Synonym Protein Names: | Ubiquitin thioesterase L3 |
| Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | UCHL3 |
| UniProt Entry Name: | UCHL3_HUMAN |
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