Epigenetics & Nuclear Signaling Antibodies 4
Anti-UBTF Antibody (CAB9847)
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- SKU:
- CAB9847
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-UBTF Antibody |
| Antibody SKU: | CAB9847 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-440 of human UBTF (NP_055048.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, MCF7, HL-60, SW620, SKOV3, Mouse kidney, Mouse brain, Mouse ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-440 of human UBTF (NP_055048.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KTPQ QLWY THEK KVYL KVRP DATT KEVK DSLG KQWS QLSD KKRL KWIH KALE QRKE YEEI MRDY IQKH PELN ISEE GITK STLT KAER QLKD KFDG RPTK PPPN SYSL YCAE LMAN MKDV PSTE RMVL CSQQ WKLL SQKE KDAY HKKC DQKK KDYE VELL RFLE SLPE EEQQ RVLG EEKM LNIN KKQA TSPA SKKP AQEG GKGG SEKP KRPV SAMF IFSE EKRR QLQE ERPE LSES ELTR L |
| Gene ID: | 7343 |
| Uniprot: | P17480 |
| Cellular Location: | Nucleus, nucleolus |
| Calculated MW: | 84kDa/89kDa |
| Observed MW: | 110kDa |
| Synonyms: | UBTF, NOR-90, UBF, UBF-1, UBF1, UBF2 |
| Background: | This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. |
| UniProt Protein Function: | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. |
| NCBI Summary: | This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P17480 |
| NCBI GenInfo Identifier: | 136652 |
| NCBI Gene ID: | 7343 |
| NCBI Accession: | P17480.1 |
| UniProt Secondary Accession: | P17480,A8K6R8, |
| UniProt Related Accession: | P17480 |
| Molecular Weight: | 84,937 Da |
| NCBI Full Name: | Nucleolar transcription factor 1 |
| NCBI Synonym Full Names: | upstream binding transcription factor, RNA polymerase I |
| NCBI Official Symbol: | UBTF |
| NCBI Official Synonym Symbols: | UBF; UBF1; UBF2; UBF-1; NOR-90 |
| NCBI Protein Information: | nucleolar transcription factor 1 |
| UniProt Protein Name: | Nucleolar transcription factor 1 |
| UniProt Synonym Protein Names: | Autoantigen NOR-90; Upstream-binding factor 1; UBF-1 |
| Protein Family: | Nucleolar transcription factor |
| UniProt Gene Name: | UBTF |
| UniProt Entry Name: | UBF1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UBTF antibody (CAB9847) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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