Autophagy Antibodies

Anti-UBQLN1 Antibody (CAB15439)

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SKU:
CAB15439
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy

Description

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Antibody Name:Anti-UBQLN1 Antibody
Antibody SKU:CAB15439
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-540 of human UBQLN1 (NP_038466.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-540 of human UBQLN1 (NP_038466.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LIPG FTPG LGAL GSTG GSSG TNGS NATP SENT SPTA GTTE PGHQ QFIQ QMLQ ALAG VNPQ L
Gene ID:29979
Uniprot:Q9UMX0
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Nucleus, autophagosome
Calculated MW:18kDa/43kDa/59kDa/62kDa
Observed MW:70kDa
Synonyms:UBQLN1, DA41, DSK2, PLIC-1, UBQN, XDRP1
Background:This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:UBQLN1: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors. Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 9q22|9q21.2-q21.3

Cellular Component: autophagic vacuole; cytoplasm; endoplasmic reticulum; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; protein complex

Molecular Function:identical protein binding; kinase binding; polyubiquitin binding; protein binding

Biological Process: autophagic vacuole formation; ER-associated protein catabolic process; macroautophagy; positive regulation of protein ubiquitination; regulation of protein ubiquitination

NCBI Summary:This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UMX0
NCBI GenInfo Identifier:48475013
NCBI Gene ID:29979
NCBI Accession:Q9UMX0.2
UniProt Secondary Accession:Q9UMX0,Q5T6J5, Q5T6J9, Q8IXS9, Q8N2Q3, Q9H0T8, Q9H3R4 Q9HAZ5,
UniProt Related Accession:Q9UMX0
Molecular Weight:18,910 Da
NCBI Full Name:Ubiquilin-1
NCBI Synonym Full Names:ubiquilin 1
NCBI Official Symbol:UBQLN1  
NCBI Official Synonym Symbols:DA41; DSK2; UBQN; XDRP1; PLIC-1  
NCBI Protein Information:ubiquilin-1
UniProt Protein Name:Ubiquilin-1
UniProt Synonym Protein Names:Protein linking IAP with cytoskeleton 1; PLIC-1; hPLIC-1
Protein Family:Ubiquilin
UniProt Gene Name:UBQLN1  
UniProt Entry Name:UBQL1_HUMAN
Anti-UBQLN1 Antibody (CAB15439)Western blot analysis of extracts of various cell lines, using UBQLN1 antibody (CAB15439) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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