Cell Biology Antibodies 14
Anti-Ubiquityl-Histone H2A-K119 Antibody (CAB17952)
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- SKU:
- CAB17952
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Ubiquityl-Histone H2A-K119 Antibody |
| Antibody SKU: | CAB17952 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human HIST1H2AB. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | NIH/3T3, C6 |
| Immunogen: | A synthetic peptide of human HIST1H2AB. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3012/8335 |
| Uniprot: | P04908 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 17KDa |
 | Western blot - Ubiquityl-Histone H2A-K119 Rabbit pAb (CAB17952) |
| Synonyms: | HIST1H2AB |
| Background: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.H2A clustered histone (H2AC) consists of several H2A family members, which function as replication-dependent histone proteins. |
| UniProt Protein Function: | HIST1H2AE: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p22.2 Cellular Component: nuclear chromatin; nucleus Molecular Function:DNA binding Biological Process: chromatin silencing; negative regulation of cell proliferation |
| NCBI Summary: | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P04908 |
| NCBI GenInfo Identifier: | 124028530 |
| NCBI Gene ID: | 3012 |
| NCBI Accession: | P04908.2 |
| UniProt Secondary Accession: | P04908,P28001, Q76P63, |
| UniProt Related Accession: | P04908 |
| Molecular Weight: | 14kDa |
| NCBI Full Name: | Histone H2A type 1-B/E |
| NCBI Synonym Full Names: | histone cluster 1 H2A family member e |
| NCBI Official Symbol: | HIST1H2AE |
| NCBI Official Synonym Symbols: | H2A.1; H2A.2; H2A/a; H2AFA |
| NCBI Protein Information: | histone H2A type 1-B/E |
| UniProt Protein Name: | Histone H2A type 1-B/E |
| UniProt Synonym Protein Names: | Histone H2A.2; Histone H2A/a; Histone H2A/m |
| UniProt Gene Name: | HIST1H2AB |
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