Metabolism Antibodies 1

Anti-UBIAD1 Antibody (CAB13421)

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SKU:
CAB13421
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-UBIAD1 Antibody
Antibody SKU:CAB13421
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human UBIAD1 (NP_037451.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:5637, Mouse kidney
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human UBIAD1 (NP_037451.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFAY AIQV GSLA IFPL VYAI PLAL STEA ILHS NNTR DMES DREA GIVT LAIL IGPT FSYI LYNT LLFL PYLV FSIL ATHC TISL ALPL LTIP MAFS LERQ FRSQ AFNK LPQR TAKL NLLL GLFY VFGI ILAP AGSL PKI
Gene ID:29914
Uniprot:Q9Y5Z9
Cellular Location:Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, Mitochondrion membrane, Multi-pass membrane protein, Nucleus
Calculated MW:19kDa/36kDa
Observed MW:37kDa
Synonyms:UBIAD1, SCCD, TERE1
Background:This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy.
UniProt Protein Function:UBIAD1: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas. Mediates the conversion of phylloquinone (PK) into menaquinone-4 (MK-4), probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Defects in UBIAD1 are the cause of crystalline corneal dystrophy of Schnyder (SCCD). SCCD is a rare autosomal dominant disease characterized by progressive corneal opacification resulting from abnormal deposition of cholesterol and phospholipids. Belongs to the UbiA prenyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.5.1.-; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to Golgi membrane; membrane; nucleus

Molecular Function:antioxidant activity; prenyltransferase activity; protein binding

Biological Process: menaquinone biosynthetic process; ubiquinone biosynthetic process; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate; vitamin K biosynthetic process; vitamin K metabolic process

Disease: Schnyder Corneal Dystrophy

NCBI Summary:This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008]
UniProt Code:Q9Y5Z9
NCBI GenInfo Identifier:1057866085
NCBI Gene ID:29914
NCBI Accession:
UniProt Secondary Accession:Q9Y5Z9,Q53GX3, Q5THD4, B3KQG3,
UniProt Related Accession:Q9Y5Z9
Molecular Weight:Calculated MW 19kDa/36kDaObserved MW 37kDa
NCBI Full Name:ubiA prenyltransferase domain-containing protein 1 isoform 2
NCBI Synonym Full Names:UbiA prenyltransferase domain containing 1
NCBI Official Symbol:UBIAD1  
NCBI Official Synonym Symbols:SCCD; TERE1  
NCBI Protein Information:ubiA prenyltransferase domain-containing protein 1
UniProt Protein Name:UbiA prenyltransferase domain-containing protein 1
UniProt Synonym Protein Names:Transitional epithelial response protein 1
Protein Family:UbiA prenyltransferase domain-containing protein
UniProt Gene Name:UBIAD1  
UniProt Entry Name:UBIA1_HUMAN
Anti-UBIAD1 Antibody (CAB13421)Western blot analysis of extracts of various cell lines, using UBIAD1 antibody (CAB13421) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
Anti-UBIAD1 Antibody (CAB13421)Immunohistochemistry of paraffin-embedded human stomach using UBIAD1 antibody (CAB13421) at dilution of 1:100 (40x lens).
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