Anti-UBE4A Antibody (CAB0710)
- SKU:
- CAB0710
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- UBE4A
- Synonyms:
- E4
- Synonyms:
- UBOX2
- Synonyms:
- UFD2
- Synonyms:
- ubiquitination factor E4A
Description
| Product Name: | UBE4A Rabbit mAb |
| Product Code: | CAB0710 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | UBE4A, E4, UBOX2, UFD2, ubiquitination factor E4A |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human UBE4A. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HUVEC, Mouse brain, Mouse kidney, Rat liver, Rat brain |
| Immunogen: | A synthesized peptide derived from human UBE4A. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9354 |
| Uniprot: | Q14139 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 123kDa |
| Observed MW: | 125KDa |
| UniProt Protein Function: | UBE4A: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3. Belongs to the ubiquitin conjugation factor E4 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19; Ligase; Ubiquitin ligase Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: cytoplasm; ubiquitin ligase complex Molecular Function:protein binding; ligase activity Biological Process: ubiquitin-dependent protein catabolic process; protein polyubiquitination |
| NCBI Summary: | This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q14139 |
| NCBI GenInfo Identifier: | 71164791 |
| NCBI Gene ID: | 9354 |
| NCBI Accession: | Q14139.2 |
| UniProt Secondary Accession: | Q14139,Q2M1H0, Q6P5T4, Q7Z639, B0YJB6, |
| UniProt Related Accession: | Q14139 |
| Molecular Weight: | 1066 |
| NCBI Full Name: | Ubiquitin conjugation factor E4 A |
| NCBI Synonym Full Names: | ubiquitination factor E4A |
| NCBI Official Symbol: | UBE4A |
| NCBI Official Synonym Symbols: | E4; UFD2; UBOX2 |
| NCBI Protein Information: | ubiquitin conjugation factor E4 A; ubiquitination factor E4A (UFD2 homolog, yeast) |
| UniProt Protein Name: | Ubiquitin conjugation factor E4 A |
| Protein Family: | Ubiquitin conjugation factor |
| UniProt Gene Name: | UBE4A |
| UniProt Entry Name: | UBE4A_HUMAN |
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