Signal Transduction Antibodies 1
Anti-UBE3C Antibody (CAB14095)
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- SKU:
- CAB14095
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-UBE3C Antibody |
| Antibody SKU: | CAB14095 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human UBE3C (NP_055486.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human UBE3C (NP_055486.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MFSF EGDF KTRP KVSL GGAS RKEE KASL LHRT QEER RKRE EERR RLKN AIII QSFI RGYR DRKQ QYSI QRSA FDRC ATLS QSGG AFPI ANGP NLTL LVRQ LLFF YKQN EDSK RLIW LYQN LIKH SSLF VKQL DGSE RLTC LFQI KRLM SLCC RLLQ NCND DSLN VALP MRML EVFS SENT YLPV LQDA SYVV SVIE QILH YMIH NGYY RSLY LLIN SKLP SSIE YSDL SRVP IAKI LLEN VLKP LHFT YNSC PEGA RQQV FTAF TEEF LA |
| Gene ID: | 9690 |
| Uniprot: | Q15386 |
| Cellular Location: | Nucleus |
| Calculated MW: | 45kDa/74kDa/123kDa |
| Observed MW: | Refer to figures |
| Synonyms: | UBE3C, HECTH2 |
| Background: |
| UniProt Protein Function: | UBE3C: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase Chromosomal Location of Human Ortholog: 7q36.3 Cellular Component: proteasome complex; cytoplasm; intracellular; nucleus Molecular Function:protein binding; ubiquitin-protein ligase activity; ligase activity Biological Process: protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process |
| UniProt Code: | Q15386 |
| NCBI GenInfo Identifier: | 67462009 |
| NCBI Gene ID: | 9690 |
| NCBI Accession: | Q15386.3 |
| UniProt Secondary Accession: | Q15386,Q8TC15, Q96CR4, Q9UDU3, A4D235, A6NCP3, |
| UniProt Related Accession: | Q15386 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin-protein ligase E3C |
| NCBI Synonym Full Names: | ubiquitin protein ligase E3C |
| NCBI Official Symbol: | UBE3C |
| NCBI Official Synonym Symbols: | HECTH2 |
| NCBI Protein Information: | ubiquitin-protein ligase E3C; ubiquitin-protein isopeptide ligase (E3) |
| UniProt Protein Name: | Ubiquitin-protein ligase E3C |
| UniProt Synonym Protein Names: | HectH2 |
| Protein Family: | Ubiquitin-protein ligase |
| UniProt Gene Name: | UBE3C |
| UniProt Entry Name: | UBE3C_HUMAN |
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