Signal Transduction Antibodies 3

Anti-UBE2V2 Antibody (CAB6998)

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SKU:
CAB6998
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-UBE2V2 Antibody
Antibody SKU:CAB6998
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human UBE2V2 (NP_003341.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SW480, SKOV3, HeLa, HL-60, Mouse liver, Mouse skin, Rat liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human UBE2V2 (NP_003341.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAVS TGVK VPRN FRLL EELE EGQK GVGD GTVS WGLE DDED MTLT RWTG MIIG PPRT NYEN RIYS LKVE CGPK YPEA PPSV RFVT KINM NGIN NSSG MVDA RSIP VLAK WQNS YSIK VVLQ ELRR LMMS KENM KLPQ PPEG QTYN N
Gene ID:7336
Uniprot:Q15819
Cellular Location:
Calculated MW:16kDa
Observed MW:16kDa
Synonyms:UBE2V2, DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2
Background:Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.
UniProt Protein Function:UBE2V2: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Belongs to the ubiquitin-conjugating enzyme family.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 8q11.21

Cellular Component: cytoplasm; nucleus; UBC13-MMS2 complex

Molecular Function:protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding

Biological Process: regulation of DNA repair; positive regulation of synaptogenesis; cell proliferation; protein polyubiquitination; positive regulation of DNA repair; postreplication repair; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; DNA double-strand break processing; protein ubiquitination; negative regulation of neuron apoptosis

NCBI Summary:Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]
UniProt Code:Q15819
NCBI GenInfo Identifier:51701935
NCBI Gene ID:7336
NCBI Accession:Q15819.4
UniProt Related Accession:Q15819
Molecular Weight:145
NCBI Full Name:Ubiquitin-conjugating enzyme E2 variant 2
NCBI Synonym Full Names:ubiquitin-conjugating enzyme E2 variant 2
NCBI Official Symbol:UBE2V2  
NCBI Official Synonym Symbols:MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1  
NCBI Protein Information:ubiquitin-conjugating enzyme E2 variant 2; DDVit 1; MMS2 homolog; vitamin D3-inducible protein; 1 alpha,25-dihydroxyvitamin D3-inducible; enterocyte differentiation promoting factor; enterocyte differentiation-promoting factor 1; enterocyte differentiation-associated factor 1; enterocyte differentiation-associated factor EDAF-1; methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 variant 2
UniProt Synonym Protein Names:DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible protein
Protein Family:Ubiquitin-conjugating enzyme
UniProt Gene Name:UBE2V2  
UniProt Entry Name:UB2V2_HUMAN
Anti-UBE2V2 Antibody (CAB6998)Western blot analysis of extracts of various cell lines, using UBE2V2 antibody (CAB6998) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-UBE2V2 Antibody (CAB6998)Immunohistochemistry of paraffin-embedded rat spleen using UBE2V2 antibody (CAB6998) at dilution of 1:100 (40x lens).
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system_update_altDatasheetHuman UBE2V2/DDVIT1 Recombinant Protein Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 c