Cell Cycle Antibodies 1
Anti-UBE2S Antibody (CAB4658)
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- SKU:
- CAB4658
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- UBE2S
- Synonyms:
- E2-EPF
- Synonyms:
- E2EPF
- Synonyms:
- EPF5
- Research Area:
- Cell Cycle
Description
| Product Name: | UBE2S Rabbit pAb |
| Product Code: | CAB4658 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | UBE2S, E2-EPF, E2EPF, EPF5 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 122-221 of human UBE2S (NP_055316.2). |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, A-431, HeLa, 22Rv1, BT-474, Mouse spleen, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 122-221 of human UBE2S (NP_055316.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HPNP ESAL NEEA GRLL LENY EEYA ARAR LLTE IHGG AGGP SGRA EAGR ALAS GTEA SSTD PGAP GGPG GAEG PMAK KHAG ERDK KLAA KKKT DKKR ALRR |
| Gene ID: | 27338 |
| Uniprot: | Q16763 |
| Calculated MW: | 23kDa |
| Observed MW: | 24kDa |
| UniProt Protein Function: | UBE2S: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL. Belongs to the ubiquitin-conjugating enzyme family. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 19q13.43 Cellular Component: anaphase-promoting complex; cytoplasm Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity Biological Process: anaphase-promoting complex activation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; protein modification process; exit from mitosis |
| NCBI Summary: | This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16763 |
| NCBI GenInfo Identifier: | 23829978 |
| NCBI Gene ID: | 27338 |
| NCBI Accession: | Q16763.2 |
| UniProt Related Accession: | Q16763 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 S |
| NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 S |
| NCBI Official Symbol: | UBE2S |
| NCBI Official Synonym Symbols: | EPF5; E2EPF; E2-EPF |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 S |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 S |
| UniProt Synonym Protein Names: | E2-EPF; Ubiquitin carrier protein S; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; Ubiquitin-protein ligase S |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2S |
| UniProt Entry Name: | UBE2S_HUMAN |
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