Signal Transduction Antibodies 2
Anti-UBE2L6 Antibody (CAB4282)
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- SKU:
- CAB4282
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-UBE2L6 Antibody |
| Antibody SKU: | CAB4282 |
| Antibody Size: | 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human UBE2L6 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | Jurkat |
| Immunogen: | A synthetic peptide of human UBE2L6 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9246 |
| Uniprot: | O14933 |
| Cellular Location: | |
| Calculated MW: | 10kDa/17kDa |
| Observed MW: | 20kDa |
| Synonyms: | UBE2L6, RIG-B, UBCH8 |
| Background: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 11q12 Cellular Component: cytosol Molecular Function:protein binding; ISG15 conjugating enzyme activity; ubiquitin-protein ligase activity; ligase activity Biological Process: modification-dependent protein catabolic process; ISG15-protein conjugation; cytokine and chemokine mediated signaling pathway; protein modification process; protein ubiquitination; innate immune response; negative regulation of interferon type I production |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | O14933 |
| NCBI GenInfo Identifier: | 239938941 |
| NCBI Gene ID: | 9246 |
| NCBI Accession: | O14933.4 |
| UniProt Related Accession: | O14933 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin/ISG15-conjugating enzyme E2 L6 |
| NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 L6 |
| NCBI Official Symbol: | UBE2L6 |
| NCBI Official Synonym Symbols: | RIG-B; UBCH8 |
| NCBI Protein Information: | ubiquitin/ISG15-conjugating enzyme E2 L6 |
| UniProt Protein Name: | Ubiquitin/ISG15-conjugating enzyme E2 L6 |
| UniProt Synonym Protein Names: | Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6 |
| UniProt Gene Name: | UBE2L6 |
| UniProt Entry Name: | UB2L6_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using UBE2L6 antibody (CAB4282). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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