Cell Cycle Antibodies 2

Anti-UBE2C Antibody (CAB5206)

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SKU:
CAB5206

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-UBE2C Antibody
Antibody SKU:CAB5206
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human UBE2C
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:HeLa, PC-3
Immunogen:A synthesized peptide derived from human UBE2C
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:11065
Uniprot:O00762
Cellular Location:
Calculated MW:20kDa
Observed MW:20KDa
Synonyms:UBCH10, dJ447F3.2
Background:The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]
UniProt Protein Function:UBE2C: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Belongs to the ubiquitin-conjugating enzyme family.
UniProt Protein Details:

Protein type:Ligase; Cell cycle regulation; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: anaphase-promoting complex; cytoplasm; cytosol; nucleoplasm

Molecular Function:protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cyclin catabolic process; exit from mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of exit from mitosis; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of mitotic metaphase/anaphase transition; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process

NCBI Summary:The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]
UniProt Code:O00762
NCBI GenInfo Identifier:3915178
NCBI Gene ID:11065
NCBI Accession:O00762.1
UniProt Secondary Accession:O00762,A6NP33, E1P5N7, G3XAB7,
UniProt Related Accession:O00762
Molecular Weight:17,373 Da
NCBI Full Name:Ubiquitin-conjugating enzyme E2 C
NCBI Synonym Full Names:ubiquitin conjugating enzyme E2 C
NCBI Official Symbol:UBE2C  
NCBI Official Synonym Symbols:UBCH10; dJ447F3.2  
NCBI Protein Information:ubiquitin-conjugating enzyme E2 C
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 C
UniProt Synonym Protein Names:(E3-independent) E2 ubiquitin-conjugating enzyme C (EC:2.3.2.24
Protein Family:Ubiquitin-conjugating enzyme
UniProt Gene Name:UBE2C  
UniProt Entry Name:UBE2C_HUMAN
Anti-UBE2C Antibody (CAB5206)Western blot - UBE2C Rabbit mAb (CAB5206)
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
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