Anti-UBE2B Antibody (CAB0503)
- SKU:
- CAB0503
Description
| Product Name: | UBE2B Rabbit mAb |
| Product Code: | CAB0503 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin-conjugating enzyme E2 B |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human UBE2B. |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, NIH/3T3, K-562, Mouse testis, Mouse heart, Rat testis |
| Immunogen: | A synthesized peptide derived from human UBE2B. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7320 |
| Uniprot: | P63146 |
| Cellular Location: | Cell membrane, Nucleus |
| Calculated MW: | 17kDa |
| Observed MW: | 17KDa |
| UniProt Protein Function: | UBE2B: a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA. |
| UniProt Protein Details: | Protein type:Ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: XY body; nuclear chromatin; cytoplasm; plasma membrane; replication fork; chromatin; nucleus Molecular Function:protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity Biological Process: response to drug; protein monoubiquitination; ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; protein stabilization; in utero embryonic development; postreplication repair; protein ubiquitination; Wnt receptor signaling pathway through beta-catenin; DNA repair; negative regulation of histone phosphorylation; cellular response to insulin stimulus; maintenance of chromatin silencing; response to hypoxia; sperm axoneme assembly; spermatogenesis; chiasma formation; response to DNA damage stimulus; histone H2A ubiquitination; response to UV; negative regulation of apoptosis |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P63146 |
| NCBI GenInfo Identifier: | 52783814 |
| NCBI Gene ID: | 7320 |
| NCBI Accession: | P63146.1 |
| UniProt Related Accession: | P63146 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 B |
| NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 B |
| NCBI Official Symbol: | UBE2B |
| NCBI Official Synonym Symbols: | HR6B; UBC2; HHR6B; RAD6B; E2-17kDa |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 B |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 B |
| UniProt Synonym Protein Names: | RAD6 homolog B; HR6B; hHR6B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2B |
| UniProt Entry Name: | UBE2B_HUMAN |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Monoclonal Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Synonyms: |
UBE2B |
Synonyms: |
E2-17kDa |
Synonyms: |
HHR6B |
Synonyms: |
HR6B |
Synonyms: |
RAD6B |
Synonyms: |
UBC2 |
Synonyms: |
ubiquitin-conjugating enzyme E2 B |
Research Area: |
Epigenetics and Nuclear Signaling |
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