Signal Transduction Antibodies 3
Anti-UBD Antibody (CAB5491)
(No reviews yet)
Write a Review
- SKU:
- CAB5491
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-UBD Antibody |
| Antibody SKU: | CAB5491 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human UBD (NP_006389.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human UBD (NP_006389.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAPN ASCL CVHV RSEE WDLM TFDA NPYD SVKK IKEH VRSK TKVP VQDQ VLLL GSKI LKPR RSLS SYGI DKEK TIHL TLKV VKPS DEEL PLFL VESG DEAK RHLL QVRR SSSV AQVK AMIE TKTG IIPE TQIV TCNG KRLE DGKM MADY GIRK GNLL FLAC YCIG G |
| Gene ID: | 10537 |
| Uniprot: | O15205 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 18kDa |
| Observed MW: | 24kDa |
| Synonyms: | UBD, FAT10, GABBR1, UBD-3 |
| Background: |
| UniProt Protein Function: | FAT10: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN). |
| UniProt Protein Details: | Protein type:Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function:protein binding Biological Process: myeloid dendritic cell differentiation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein modification by small protein conjugation; protein ubiquitination; proteolysis; response to organic nitrogen; ubiquitin-dependent protein catabolic process |
| UniProt Code: | O15205 |
| NCBI GenInfo Identifier: | 269849476 |
| NCBI Gene ID: | 10537 |
| NCBI Accession: | O15205.2 |
| UniProt Secondary Accession: | O15205,Q5STL2, Q5SUK2, Q96EC7, B0UZT6, |
| UniProt Related Accession: | O15205 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin D |
| NCBI Synonym Full Names: | ubiquitin D |
| NCBI Official Symbol: | UBD |
| NCBI Official Synonym Symbols: | FAT10; UBD-3; GABBR1 |
| NCBI Protein Information: | ubiquitin D |
| UniProt Protein Name: | Ubiquitin D |
| UniProt Synonym Protein Names: | Diubiquitin; Ubiquitin-like protein FAT10 |
| Protein Family: | Ubiquitin |
| UniProt Gene Name: | UBD |
| UniProt Entry Name: | UBD_HUMAN |
 | Western blot analysis of extracts of mouse liver, using UBD antibody (CAB5491) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of A-549 cells using UBD antibody (CAB5491). Blue: DAPI for nuclear staining. |
View AllClose
Related Products
