Cell Biology Antibodies 11
Anti-UBASH3B Antibody (CAB7141)
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- SKU:
- CAB7141
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-UBASH3B Antibody |
| Antibody SKU: | CAB7141 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human UBASH3B (NP_116262.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, SKOV3, Mouse brain, Mouse spleen, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human UBASH3B (NP_116262.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAQY GHPS PLGM AARE ELYS KVTP RRNR QQRP GTIK HGSA LDVL LSMG FPRA RAQK ALAS TGGR SVQA ACDW LFSH VGDP FLDD PLPR EYVL YLRP TGPL AQKL SDFW QQSK QICG KNKA HNIF PHIT LCQF FMCE DSKV DALG EALQ TTVS RWKC KFSA PLPL ELYT SSNF IGLF VKED SAEV LKKF AADF AAEA ASKT EVHV EPHK KQLH VTLA YHFQ ASHL PTLE KLAQ NIDV KLGC DWVA TIFS RDIR FANH ETLQ VIYP YTPQ NDDE LELV PGDF IFMS PMEQ TSTS EGWI YGTS |
| Gene ID: | 84959 |
| Uniprot: | Q8TF42 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 72kDa |
| Observed MW: | 72kDa |
| Synonyms: | UBASH3B, STS-1, STS1, TULA-2, TULA2, p70 |
| Background: | This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. |
| UniProt Protein Function: | STS-1: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. |
| UniProt Protein Details: | Protein type:EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 11q24.1 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; protein tyrosine phosphatase activity Biological Process: negative regulation of protein kinase activity; regulation of release of sequestered calcium ion into cytosol |
| NCBI Summary: | This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TF42 |
| NCBI GenInfo Identifier: | 110287974 |
| NCBI Gene ID: | 84959 |
| NCBI Accession: | Q8TF42.2 |
| UniProt Related Accession: | Q8TF42 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin-associated and SH3 domain-containing protein B |
| NCBI Synonym Full Names: | ubiquitin associated and SH3 domain containing B |
| NCBI Official Symbol: | UBASH3B |
| NCBI Official Synonym Symbols: | p70; STS1; STS-1; TULA2; TULA-2 |
| NCBI Protein Information: | ubiquitin-associated and SH3 domain-containing protein B |
| UniProt Protein Name: | Ubiquitin-associated and SH3 domain-containing protein B |
| UniProt Synonym Protein Names: | Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; STS-1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2 |
| UniProt Gene Name: | UBASH3B |
| UniProt Entry Name: | UBS3B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UBASH3B antibody (CAB7141) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using UBASH3B antibody (CAB7141) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of A549 cells using UBASH3B antibody (CAB7141). Blue: DAPI for nuclear staining. |
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