Anti-UBA7 Antibody (CAB9142)

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SKU:
CAB9142
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
UBA7
Synonyms:
D8
Synonyms:
UBA1B
Synonyms:
UBE1L
Synonyms:
UBE2

Description

Product Name:UBA7 Rabbit pAb
Product Code:CAB9142
Size:20uL, 50uL, 100uL
Synonyms:UBA7, D8, UBA1B, UBE1L, UBE2
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 723-1012 of human UBA7 (NP_003326.2).
Applications:WB
Recommended Dilutions:WB 1:200 - 1:2000
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 723-1012 of human UBA7 (NP_003326.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:THLL YVLA AANL YAQM HGLP GSQD WTAL RELL KLLP QPDP QQMA PIFA SNLE LASA SAEF GPEQ QKEL NKAL EVWS VGPP LKPL MFEK DDDS NFHV DFVV AAAS LRCQ NYGI PPVN RAQS KRIV GQII PAIA TTTA AVAG LLGL ELYK VVSG PRPR SAFR HSYL HLAE NYLI RYMP FAPA IQTF HHLK WTSW DRLK VPAG QPER TLES LLAH LQEQ HGLR VRIL LHGS ALLY AAGW SPEK QAQH LPLR VTEL VQQL TGQA PAPG QRVL VLEL SCEG DDED TAFP PLHY EL
Gene ID:7318
Uniprot:P41226
Calculated MW:111kDa
Observed MW:Refer to figures
UniProt Protein Function:UBE1L: Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Belongs to the ubiquitin-activating E1 family.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function:ISG15 activating enzyme activity; protein binding; ubiquitin activating enzyme activity; ubiquitin-protein ligase activity

Biological Process: bypass DNA synthesis; ISG15-protein conjugation; modification-dependent protein catabolic process; negative regulation of interferon type I production; protein modification process

NCBI Summary:The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
UniProt Code:P41226
NCBI GenInfo Identifier:215273977
NCBI Gene ID:7318
NCBI Accession:P41226.2
UniProt Secondary Accession:P41226,Q9BRB2,
UniProt Related Accession:P41226
Molecular Weight:111,694 Da
NCBI Full Name:Ubiquitin-like modifier-activating enzyme 7
NCBI Synonym Full Names:ubiquitin like modifier activating enzyme 7
NCBI Official Symbol:UBA7  
NCBI Official Synonym Symbols:D8; UBE2; UBA1B; UBE1L  
NCBI Protein Information:ubiquitin-like modifier-activating enzyme 7
UniProt Protein Name:Ubiquitin-like modifier-activating enzyme 7
UniProt Synonym Protein Names:D8; Ubiquitin-activating enzyme E1 homolog
Protein Family:Ubiquitin-like modifier-activating enzyme
UniProt Gene Name:UBA7  
UniProt Entry Name:UBA7_HUMAN
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