Signal Transduction Antibodies 3
Anti-UBA1 Antibody (CAB9254)
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- SKU:
- CAB9254
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-UBA1 Antibody |
| Antibody SKU: | CAB9254 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human UBA1 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, K-562, Mouse testis, Mouse brain, Mouse spleen, Rat brain |
| Immunogen: | A synthesized peptide derived from human UBA1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7317 |
| Uniprot: | P22314 |
| Cellular Location: | |
| Calculated MW: | 118kDa |
| Observed MW: | 110-118KDa |
| Synonyms: | A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X |
| Background: | The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | UBE1: an enzyme of the ubiquitin-activating E1 family. Adenylates ubiquitin at its carboxy-terminal glycine residue and thereafter links this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester. There are two active sites within the E1 molecule, allowing it to accomodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: heterochromatin; desmosome; mitochondrion; lysosomal membrane; cytoplasm; endosome membrane; rough endoplasmic reticulum membrane; nucleus; cytosol Molecular Function:protein binding; ubiquitin-protein ligase activity; ubiquitin activating enzyme activity; ATP binding Biological Process: modification-dependent protein catabolic process; protein ubiquitination; response to DNA damage stimulus Disease: Spinal Muscular Atrophy, X-linked 2 |
| NCBI Summary: | The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P22314 |
| NCBI GenInfo Identifier: | 24418865 |
| NCBI Gene ID: | 7317 |
| NCBI Accession: | P22314.3 |
| UniProt Secondary Accession: | P22314,Q5JRR8, Q96E13, |
| UniProt Related Accession: | P22314 |
| Molecular Weight: | 1058 |
| NCBI Full Name: | Ubiquitin-like modifier-activating enzyme 1 |
| NCBI Synonym Full Names: | ubiquitin-like modifier activating enzyme 1 |
| NCBI Official Symbol: | UBA1 |
| NCBI Official Synonym Symbols: | A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; POC20; SMAX2; UBA1A; UBE1X; CFAP124 |
| NCBI Protein Information: | ubiquitin-like modifier-activating enzyme 1; POC20 centriolar protein homolog; UBA1, ubiquitin-activating enzyme E1 homolog A; A1S9T and BN75 temperature sensitivity complementing |
| UniProt Protein Name: | Ubiquitin-like modifier-activating enzyme 1 |
| UniProt Synonym Protein Names: | Protein A1S9; Ubiquitin-activating enzyme E1 |
| UniProt Gene Name: | UBA1 |
| UniProt Entry Name: | UBA1_HUMAN |
 | Western blot - UBA1 Rabbit mAb (CAB9254) |
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