Cell Biology Antibodies 8

Anti-UAP1 Antibody (CAB2119)

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SKU:
CAB2119
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-UAP1 Antibody
Antibody SKU:CAB2119
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human UAP1 (NP_003106.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:HepG2, HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human UAP1 (NP_003106.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNIN DLKL TLSK AGQE HLLR FWNE LEEA QQVE LYAE LQAM NFEE LNFF FQKA IEGF NQSS HQKN VDAR MEPV PREV LGSA TRDQ DQLQ AWES EGLF QISQ NKVA VLLL AGGQ GTRL GVAY PKGM YDVG LPSR KTLF QIQA ERIL KLQQ VAEK YYGN KCII PWYI MTSG RTME STKE FFTK HKYF GLKK ENVI FFQQ GMLP AMSF DGKI ILEE KNKV SMAP DGNG GLYR ALAA QNIV EDME QRGI WSIH VYCV DNIL VKVA DPRF IGFC IQKG ADCG AKVV EKTN PTEP VG
Gene ID:6675
Uniprot:Q16222
Cellular Location:Cytoplasm
Calculated MW:57kDa/58kDa
Observed MW:59kDa
Synonyms:UAP1, AGX, AGX1, AGX2, SPAG2
Background:
UniProt Protein Function:UAP1: Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P. Belongs to the UDPGP type 1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transferase; EC 2.7.7.23; EC 2.7.7.83; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function:UDP-N-acetylglucosamine diphosphorylase activity; carbohydrate binding

Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; UDP-N-acetylglucosamine biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

UniProt Code:Q16222
NCBI GenInfo Identifier:68846235
NCBI Gene ID:6675
NCBI Accession:Q16222.3
UniProt Secondary Accession:Q16222,Q91YN5,
UniProt Related Accession:Q16222
Molecular Weight:
NCBI Full Name:UDP-N-acetylhexosamine pyrophosphorylase
NCBI Synonym Full Names:UDP-N-acetylglucosamine pyrophosphorylase 1
NCBI Official Symbol:UAP1  
NCBI Official Synonym Symbols:AGX; AGX1; AGX2; SPAG2  
NCBI Protein Information:UDP-N-acetylhexosamine pyrophosphorylase
UniProt Protein Name:UDP-N-acetylhexosamine pyrophosphorylase
UniProt Synonym Protein Names:Antigen X; AGX; Sperm-associated antigen 2Including the following 2 domains:UDP-N-acetylgalactosamine pyrophosphorylase (EC:2.7.7.83)Alternative name(s):AGX-1
Protein Family:UDP-N-acetylhexosamine pyrophosphorylase
UniProt Gene Name:UAP1  
UniProt Entry Name:UAP1_HUMAN
Anti-UAP1 Antibody (CAB2119)Western blot analysis of extracts of various cell lines, using UAP1 antibody (CAB2119) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
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