Cell Biology Antibodies 12
Anti-UACA Antibody (CAB9713)
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- SKU:
- CAB9713
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-UACA Antibody |
| Antibody SKU: | CAB9713 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human UACA (NP_060473.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, 293T, HT-1080, SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human UACA (NP_060473.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKSL KSRL RRQD VPGP ASSG AAAA SAHA ADWN KYDD RLMK AAER GDVE KVTS ILAK KGVN PGKL DVEG RSVF HVVT SKGN LECL NAIL IH |
| Gene ID: | 55075 |
| Uniprot: | Q9BZF9 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton |
| Calculated MW: | 161kDa/162kDa |
| Observed MW: | 162kDa |
| Synonyms: | UACA, NUCLING |
| Background: |
| UniProt Protein Function: | UACA: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 15q22-q24 Cellular Component: nucleoplasm; cytoskeleton; membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; extracellular region; nuclear envelope; nucleus; apoptosome Molecular Function:protein binding Biological Process: positive regulation of protein import into nucleus; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of inflammatory response; positive regulation of caspase activity; negative regulation of NF-kappaB import into nucleus; induction of apoptosis by oxidative stress; response to UV |
| UniProt Code: | Q9BZF9 |
| NCBI GenInfo Identifier: | 56550047 |
| NCBI Gene ID: | 55075 |
| NCBI Accession: | NP_001008225.1 |
| UniProt Secondary Accession: | Q9BZF9,Q14DD3, Q8N3B8, Q96NH6, Q9HCL1, Q9NWC6, G3XAG2 |
| UniProt Related Accession: | Q9BZF9 |
| Molecular Weight: | 162,505 Da |
| NCBI Full Name: | uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 2 |
| NCBI Synonym Full Names: | uveal autoantigen with coiled-coil domains and ankyrin repeats |
| NCBI Official Symbol: | UACA |
| NCBI Official Synonym Symbols: | NUCLING |
| NCBI Protein Information: | uveal autoantigen with coiled-coil domains and ankyrin repeats; nuclear membrane binding protein; uveal autoantigen with coiled coil domains and ankyrin repeats |
| UniProt Protein Name: | Uveal autoantigen with coiled-coil domains and ankyrin repeats |
| Protein Family: | Uveal autoantigen with coiled-coil domains and ankyrin repeats |
| UniProt Gene Name: | UACA |
| UniProt Entry Name: | UACA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UACA antibody (CAB9713) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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