Cell Biology Antibodies 12

Anti-UACA Antibody (CAB9713)

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SKU:
CAB9713
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-UACA Antibody
Antibody SKU:CAB9713
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human UACA (NP_060473.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, 293T, HT-1080, SKOV3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human UACA (NP_060473.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKSL KSRL RRQD VPGP ASSG AAAA SAHA ADWN KYDD RLMK AAER GDVE KVTS ILAK KGVN PGKL DVEG RSVF HVVT SKGN LECL NAIL IH
Gene ID:55075
Uniprot:Q9BZF9
Cellular Location:Cytoplasm, Nucleus, cytoskeleton
Calculated MW:161kDa/162kDa
Observed MW:162kDa
Synonyms:UACA, NUCLING
Background:
UniProt Protein Function:UACA: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 15q22-q24

Cellular Component: nucleoplasm; cytoskeleton; membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; extracellular region; nuclear envelope; nucleus; apoptosome

Molecular Function:protein binding

Biological Process: positive regulation of protein import into nucleus; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of inflammatory response; positive regulation of caspase activity; negative regulation of NF-kappaB import into nucleus; induction of apoptosis by oxidative stress; response to UV

UniProt Code:Q9BZF9
NCBI GenInfo Identifier:56550047
NCBI Gene ID:55075
NCBI Accession:NP_001008225.1
UniProt Secondary Accession:Q9BZF9,Q14DD3, Q8N3B8, Q96NH6, Q9HCL1, Q9NWC6, G3XAG2
UniProt Related Accession:Q9BZF9
Molecular Weight:162,505 Da
NCBI Full Name:uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 2
NCBI Synonym Full Names:uveal autoantigen with coiled-coil domains and ankyrin repeats
NCBI Official Symbol:UACA  
NCBI Official Synonym Symbols:NUCLING  
NCBI Protein Information:uveal autoantigen with coiled-coil domains and ankyrin repeats; nuclear membrane binding protein; uveal autoantigen with coiled coil domains and ankyrin repeats
UniProt Protein Name:Uveal autoantigen with coiled-coil domains and ankyrin repeats
Protein Family:Uveal autoantigen with coiled-coil domains and ankyrin repeats
UniProt Gene Name:UACA  
UniProt Entry Name:UACA_HUMAN
Anti-UACA Polyclonal Antibody (CAB9713)Western blot analysis of extracts of various cell lines, using UACA antibody (CAB9713) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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