Epigenetics & Nuclear Signaling Antibodies 4

Anti-U2AF1L4 Antibody (CAB7151)

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SKU:
CAB7151
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-U2AF1L4 Antibody
Antibody SKU:CAB7151
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human U2AF1L4 (NP_659424.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human U2AF1L4 (NP_659424.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAEY LASI FGTE KDKV NCSF YFKI GVCR HGDR CSRL HNKP TFSQ EVFT ELQE KYGE IEEM NVCD NLGD HLVG NVYV KFRR EEDG ERAV AELS NRWF NGQA VHGN VPEV ASAT SCIC GPFP RTSR GSSM GGDP GAGH PRGS ILAT IPER GTIG VPLI TGMA ASEA LAPL PFTP NRDR CSWQ DLSS KPPS LSCP ILPR LPGS IM
Gene ID:199746
Uniprot:Q8WU68
Cellular Location:Cytoplasm, Nucleus, Nucleus speckle
Calculated MW:21kDa/22kDa/25kDa
Observed MW:Refer to figures
Synonyms:U2AF1L4, U2AF1-RS3, U2AF1L3, U2AF1L3V1, U2AF1RS3, U2af26
Background:
UniProt Protein Function:U2AF1L4: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Belongs to the splicing factor SR family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA splicing

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: spliceosome; cytoplasm; nuclear speck

Molecular Function:RNA binding; metal ion binding; nucleotide binding

Biological Process: RNA splicing; mRNA processing

UniProt Code:Q8WU68
NCBI GenInfo Identifier:160358766
NCBI Gene ID:199746
NCBI Accession:Q8WU68.2
UniProt Secondary Accession:Q8WU68,Q56UU3, A6NKI8,
UniProt Related Accession:Q8WU68
Molecular Weight:220
NCBI Full Name:Splicing factor U2AF 26 kDa subunit
NCBI Synonym Full Names:U2 small nuclear RNA auxiliary factor 1-like 4
NCBI Official Symbol:U2AF1L4  
NCBI Official Synonym Symbols:U2af26; U2AF1L3; U2AF1RS3; U2AF1-RS3; U2AF1L3V1  
NCBI Protein Information:splicing factor U2AF 26 kDa subunit; U2AF1-like 4; U2AF1-like protein 3; U2 auxiliary factor 26; U2 small nuclear RNA auxiliary factor 1-like 3; U2(RNU2) small nuclear RNA auxiliary factor 1-like 3; U2 small nuclear RNA auxiliary factor 1-like protein 3; U2 small nuclear RNA auxiliary factor 1-like protein 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3
UniProt Protein Name:Splicing factor U2AF 26 kDa subunit
UniProt Synonym Protein Names:U2 auxiliary factor 26U2 small nuclear RNA auxiliary factor 1-like protein 4
Protein Family:Splicing factor
UniProt Gene Name:U2AF1L4  
UniProt Entry Name:U2AF4_HUMAN
Anti-U2AF1L4 Antibody (CAB7151)Immunofluorescence analysis of A-549 cells using U2AF1L4 antibody (CAB7151). Blue: DAPI for nuclear staining.
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