Description
| Antibody Name: | Anti-U1A Antibody |
| Antibody SKU: | CAB3686 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human U1A |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, U-937, Rat brain |
| Immunogen: | A synthesized peptide derived from human U1A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6626 |
| Uniprot: | P09012 |
| Cellular Location: | |
| Calculated MW: | 31kDa |
| Observed MW: | 35KDa |
| Synonyms: | Mud1, U1-A, U1A |
| Background: | The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010] |
| UniProt Protein Function: | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. |
| NCBI Summary: | The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010] |
| UniProt Code: | P09012 |
| NCBI GenInfo Identifier: | 134092 |
| NCBI Gene ID: | 6626 |
| NCBI Accession: | P09012.3 |
| UniProt Related Accession: | P09012 |
| Molecular Weight: | 282 |
| NCBI Full Name: | U1 small nuclear ribonucleoprotein A |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein polypeptide A |
| NCBI Official Symbol: | SNRPA |
| NCBI Official Synonym Symbols: | U1A; Mud1; U1-A |
| NCBI Protein Information: | U1 small nuclear ribonucleoprotein A; U1 snRNP A; U1 snRNP-specific protein A; U1 small nuclear RNP-specific A |
| UniProt Protein Name: | U1 small nuclear ribonucleoprotein A |
| Protein Family: | U1 small nuclear ribonucleoprotein |
| UniProt Gene Name: | SNRPA |
| UniProt Entry Name: | SNRPA_HUMAN |
 | Western blot - U1A Rabbit mAb (CAB3686) |
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