Metabolism Antibodies 3
Anti-TYR Antibody (CAB16993)
- SKU:
- CAB16993
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-TYR Antibody |
| Antibody SKU: | CAB16993 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TYR. |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | A-431, A375, HepG2, Jurkat |
| Immunogen: | Recombinant protein of human TYR. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7299 |
| Uniprot: | P14679 |
| Cellular Location: | Melanosome membrane, Single-pass type I membrane protein |
| Calculated MW: | 42kDa/60kDa |
| Observed MW: | 70kDa |
 | Western blot - TYR Rabbit pAb (CAB16993) |
| Synonyms: | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 |
| Background: | The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. |
| UniProt Protein Function: | TYR: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - tyrosine; EC 1.14.18.1; Membrane protein, integral; Cofactor and Vitamin Metabolism - riboflavin; Oxidoreductase Chromosomal Location of Human Ortholog: 11q14.3 Cellular Component: lysosome; perinuclear region of cytoplasm; cytoplasm; melanosome membrane; integral to membrane; melanosome; Golgi-associated vesicle Molecular Function:protein binding; copper ion binding; protein homodimerization activity; protein heterodimerization activity; monophenol monooxygenase activity Biological Process: cell proliferation; visual perception; thymus development; melanin biosynthetic process from tyrosine; eye pigment biosynthetic process Disease: Albinism, Ocular, With Sensorineural Deafness; Albinism, Oculocutaneous, Type Ib; Albinism, Oculocutaneous, Type Ia; Skin/hair/eye Pigmentation, Variation In, 3 |
| NCBI Summary: | The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P14679 |
| NCBI GenInfo Identifier: | 401235 |
| NCBI Gene ID: | 7299 |
| NCBI Accession: | P14679.3 |
| UniProt Secondary Accession: | P14679,Q15675, Q15676, Q15680, Q8TAK4, Q9BYY0, Q9BZX1 |
| UniProt Related Accession: | P14679 |
| Molecular Weight: | Calculated MW: 42kDa/60kDaObserved MW: 80kDa |
| NCBI Full Name: | Tyrosinase |
| NCBI Synonym Full Names: | tyrosinase |
| NCBI Official Symbol: | TYR |
| NCBI Official Synonym Symbols: | ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3 |
| NCBI Protein Information: | tyrosinase; LB24-AB; SK29-AB; monophenol monooxygenase; oculocutaneous albinism IA; tumor rejection antigen AB |
| UniProt Protein Name: | Tyrosinase |
| UniProt Synonym Protein Names: | LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB |
| Protein Family: | Tyrosinase |
| UniProt Gene Name: | TYR |
| UniProt Entry Name: | TYRO_HUMAN |
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