Cell Biology Antibodies 8

Anti-TYK2 Antibody (CAB2128)

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SKU:
CAB2128
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TYK2 Antibody
Antibody SKU:CAB2128
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 750-850 of human TYK2 (NP_003322.3).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, Jurkat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 750-850 of human TYK2 (NP_003322.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GTSP FIKL SDPG VGLG ALSR EERV ERIP WLAP ECLP GGAN SLST AMDK WGFG ATLL EICF DGEA PLQS RSPS EKEH FYQR QHRL PEPS CPQL ATLT SQCL T
Gene ID:7297
Uniprot:P29597
Cellular Location:
Calculated MW:133kDa
Observed MW:134kDa
Synonyms:TYK2, IMD35, JTK1
Background:This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
UniProt Protein Function:Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain.
UniProt Protein Details:

Protein type:Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; nucleus; cytosol

Molecular Function:protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding

Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation

Disease: Immunodeficiency 35

NCBI Summary:This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
UniProt Code:P29597
NCBI GenInfo Identifier:56405328
NCBI Gene ID:7297
NCBI Accession:P29597.3
UniProt Secondary Accession:P29597,Q6QB10, Q96CH0,
UniProt Related Accession:P29597
Molecular Weight:1187
NCBI Full Name:Non-receptor tyrosine-protein kinase TYK2
NCBI Synonym Full Names:tyrosine kinase 2
NCBI Official Symbol:TYK2  
NCBI Official Synonym Symbols:JTK1; IMD35  
NCBI Protein Information:non-receptor tyrosine-protein kinase TYK2
UniProt Protein Name:Non-receptor tyrosine-protein kinase TYK2
Protein Family:Non-receptor tyrosine-protein kinase
UniProt Gene Name:TYK2  
UniProt Entry Name:TYK2_HUMAN
Anti-TYK2 Antibody (CAB2128)Western blot analysis of extracts of various cell lines, using TYK2 antibody (CAB2128) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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